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Ethanol Consumption by Wistar Rat Dams Affects Selenium Bioavailability and Antioxidant Balance in Their Progeny
Department of Physiology and Zoology, Faculty of Pharmacy, Seville University /c/ Tramontana s/n. C.P. 41012. Seville, Spain
* Author to whom correspondence should be addressed.
Received: 3 July 2009; Accepted: 22 July 2009 / Published: 30 July 2009
Abstract: Ethanol consumption affects maternal nutrition, the mothers’ antioxidant balance and the future health of their progeny. Selenium (Se) is a trace element cofactor of the enzyme glutathione peroxidase (GPx). We will study the effect of ethanol on Se bioavailability in dams and in their progeny. We have used three experimental groups of dams: control, chronic ethanol and pair-fed; and three groups of pups. Se levels were measured by graphite-furnace atomic absorption spectrometry. Serum and hepatic GPx activity was determined by spectrometry. We have concluded that ethanol decreased Se retention in dams, affecting their tissue Se deposits and those of their offspring, while also compromising their progeny’s weight and oxidation balance. These effects of ethanol are caused by a reduction in Se intake and a direct alcohol-generated oxidation action.
Keywords: Wistar rats; selenium bioavailability; ethanol; gestation; lactation; glutathione peroxidase
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Ojeda, M.L.; Vázquez, B.; Nogales, F.; Murillo, M.L.; Carreras, O. Ethanol Consumption by Wistar Rat Dams Affects Selenium Bioavailability and Antioxidant Balance in Their Progeny. Int. J. Environ. Res. Public Health 2009, 6, 2139-2149.
Ojeda ML, Vázquez B, Nogales F, Murillo ML, Carreras O. Ethanol Consumption by Wistar Rat Dams Affects Selenium Bioavailability and Antioxidant Balance in Their Progeny. International Journal of Environmental Research and Public Health. 2009; 6(8):2139-2149.
Ojeda, María Luisa; Vázquez, Beatriz; Nogales, Fátima; Murillo, María Luisa; Carreras, Olimpia. 2009. "Ethanol Consumption by Wistar Rat Dams Affects Selenium Bioavailability and Antioxidant Balance in Their Progeny." Int. J. Environ. Res. Public Health 6, no. 8: 2139-2149.