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Int. J. Environ. Res. Public Health 2009, 6(3), 999-1009; doi:10.3390/ijerph6030999
Article

Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects

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Received: 4 January 2009; Accepted: 4 March 2009 / Published: 6 March 2009
(This article belongs to the Special Issue Public Health: Feature Papers)
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Abstract: This cross-sectional study investigated the relationship between the aminolevulinate dehydrogenase (ALAD) genotype and blood lead levels among 101 Japanese workers. Blood lead concentration measurement, biomarkers, and genotyping were performed. The minor allele frequency (MAF) for ALAD (ALAD2) was 0.08. Although the blood lead level in the subjects with heterozygous GC genotype was significantly higher than those with homozygous GG genotype, there were no significant differences for hemoglobin, hematocrit, serum and urinary ALA levels among genotypes. ALAD2 genotype was significantly associated with the blood lead concentration, even in the environmental lead exposed subjects. Further confirmation with a large sample size is needed.
Keywords: ALAD gene; blood lead level; environmentally lead exposure; Japanese ALAD gene; blood lead level; environmentally lead exposure; Japanese
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Miyaki, K.; Lwin, H.; Masaki, K.; Song, Y.; Takahashi, Y.; Muramatsu, M.; Nakayama, T. Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects. Int. J. Environ. Res. Public Health 2009, 6, 999-1009.

AMA Style

Miyaki K, Lwin H, Masaki K, Song Y, Takahashi Y, Muramatsu M, Nakayama T. Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects. International Journal of Environmental Research and Public Health. 2009; 6(3):999-1009.

Chicago/Turabian Style

Miyaki, Koichi; Lwin, Htay; Masaki, Katsunori; Song, Yixuan; Takahashi, Yoshimitsu; Muramatsu, Masaaki; Nakayama, Takeo. 2009. "Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects." Int. J. Environ. Res. Public Health 6, no. 3: 999-1009.


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