Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women
Abstract
:Introduction
Materials and Methods
Subjects
Reagents and Blood Sample Collection
Clinical Chemistry
Oxidative Stress
Statistical Analysis
Results
Clinical Characteristics
Metabolic Profile
Oxidative Stress Markers
Discussion
Conclusions
Characteristic | Mean ± SD |
---|---|
Age (years) | 51.8 ± 4.47 |
Body weight (Kg) | 61.59 ± 6.77 |
Height (m) | 1.53 ± 0.04 |
BMI (Kg/m2) | 26.18 ± 2.85 |
Systolic blood pressure* (mmHg) (mmHg) | 112.5 ± 8.56 |
Diastolic blood pressure* (mmHg) | 71.13 ± 8.56 |
FSH (mIU/ml) | 57.90±32.65 |
Parameter | Week 0 | Week 6 | Week 12 | Week 18 (Washout) | p |
---|---|---|---|---|---|
Glucose | 96.88±6.722 | 98.38±6.479 | 97.13±5.427 | 93.81±8.183 | NS |
Glycated hemoglobin (%) | 3.894±0.2175 | 3.625±0.274 | 3.131±0.2414 | 3.244±0.1590 | 0 vs 6, p <0.001 0 vs 12, p <0.001 0 vs 18, p <0.001 6 vs 12, p <0.001 6 vs 18, p <0.001 12 vs 18, p >0.05 |
Uric Acid | 4.669±0.6416 | 4.325±0.591 | 4.281±0.7556 | 4.594±0.8410 | NS |
Cholesterol | 196.9±33.75 | 192.2±36.60 | 196.7±35.11 | 194.0±42.52 | NS |
Low density lipoproteins | 108±33.28 | 107.2±34.96 | 110.6±34.90 | 117.2±41.38 | NS |
High density lipoproteins | 56.50±13.36 | 53.06±9.19 | 53.19±9.955 | 48.75±11.76 | NS |
Cholesterol/High density lipoproteins | 3.614±0.768 | 3.718±0.5099 | 3.823±0.9976 | 4.129±0.970 | NS |
Triglycerides | 162.1±66.18 | 159.80±72.71 | 164.7±66.98 | 140.2±48.73 | NS |
Phosphates | 3.650±0.547 | 3.494±0.763 | 3.869±0.490 | 3.40±0.4351 | NS |
Magnesium | 2.089±0.2157 | 2.104±0.1120 | 2.305±0.1423 | 2.024±0.2055 | 0 vs 12, p <0.01 6 vs 12, p <0.05 12 vs 18, p <0.001 |
Retinol | 45.86±7.966 | 44.60±7.682 | 47.6±8.1 | 43.5±6.9 | NS |
Acknowledgments
- Author’s contributions: JDM, JCDZ, GCV and RMS participated in the study design. JLBC coordinated the trial, performed the analytic assays and wrote the initial draft of the manuscript. GCV, JDM, HRA and JCDZ assisted in the interpretation of the results and contributed to the editing and review of the manuscript.
References
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Ble-Castillo, J.L.; Cleva-Villanueva, G.; Díaz-Zagoya, J.C.; Medina-Santillán, R.; Rubio-Arias, H.O.; Méndez, J.D. Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women. Int. J. Environ. Res. Public Health 2007, 4, 260-267. https://doi.org/10.3390/ijerph200704040001
Ble-Castillo JL, Cleva-Villanueva G, Díaz-Zagoya JC, Medina-Santillán R, Rubio-Arias HO, Méndez JD. Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women. International Journal of Environmental Research and Public Health. 2007; 4(4):260-267. https://doi.org/10.3390/ijerph200704040001
Chicago/Turabian StyleBle-Castillo, J. L., G. Cleva-Villanueva, J. C. Díaz-Zagoya, R. Medina-Santillán, H. O. Rubio-Arias, and J. D. Méndez. 2007. "Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women" International Journal of Environmental Research and Public Health 4, no. 4: 260-267. https://doi.org/10.3390/ijerph200704040001