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Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women
General Hospital, Zone 46, IMSS, Prolongación de Avenida Universidad Km 2.5, Colonia Casa Blanca, 86060, Villahermosa, Tabasco, México
Research Station in DACS, Juarez Autonomous University of Tabasco, Ave. Universidad No 2890, Colonia Tamulte, Villahermosa Tabasco, C.P. 86100, México
Superior Medicine School of the National Polytechnic Institute, México, D.F., México
Faculty of Medicine, National Autonomous University of Mexico, México D.F., México
Faculty of Zootechnic, Autonomous University of Chihuahua, Mexico
Hospital de Especialidades, CMN Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores 06725, México D.F., México
* Author to whom correspondence should be addressed.
Received: 1 October 2007; Accepted: 30 November 2007 / Published: 31 December 2007
Abstract: Despite extensive research, the effects of α-tocopherol supplementation remain controversial. Few studies have been focused on obese and overweight people. We examined the effects of α-tocopherol (AT) on the oxidative status and metabolic profile in overweight women. Sixteen overweight women between the ages of 40-60 years old, received AT, 800 IU/day during 12 weeks, followed by a 6-week washout period. Blood samples were taken at the beginning and then every 6 weeks until the end of the study. AT, retinol, malondialdehyde (MDA), total antioxidant status (TAS), selenium-dependent glutathione peroxidase (GPx) and CuZn-superoxide dismutase (SOD) were quantified to evaluate the oxidative stress. The metabolic profile was estimated by measuring glycated hemoglobin (HbA1c) in erythrocytes and glucose, phosphate, magnesium, lipid and lipoprotein concentrations in serum. Under AT administration HbA1c, serum- MDA levels and erythrocyte GPx activity were markedly reduced. TAS, AT and Mg2+ concentrations in serum and SOD activity in erythrocytes were higher after AT treatment. Body weight; glucose, lipid and retinol concentrations, or blood cells count were unchanged. Lipid peroxidation was considerably reduced in AT treated women and also improved serum antioxidant status was observed, but the imbalanced response between erythrocyte SOD and GPx activities could affect normal response to oxidative stress.
Keywords: α-tocopherol; oxidative stress; lipid peroxidation; overweight
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Ble-Castillo, J.L.; Cleva-Villanueva, G.; Díaz-Zagoya, J.C.; Medina-Santillán, R.; Rubio-Arias, H.O.; Méndez, J.D. Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women. Int. J. Environ. Res. Public Health 2007, 4, 260-267.
Ble-Castillo JL, Cleva-Villanueva G, Díaz-Zagoya JC, Medina-Santillán R, Rubio-Arias HO, Méndez JD. Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women. International Journal of Environmental Research and Public Health. 2007; 4(4):260-267.
Ble-Castillo, J. L.; Cleva-Villanueva, G.; Díaz-Zagoya, J. C.; Medina-Santillán, R.; Rubio-Arias, H. O.; Méndez, J. D. 2007. "Effects of α-Tocopherol on Oxidative Status and Metabolic Profile in Overweight Women." Int. J. Environ. Res. Public Health 4, no. 4: 260-267.