Int. J. Environ. Res. Public Health 2006, 3(4), 348-354; doi:10.3390/ijerph2006030045
Article

Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

Hongtao Yu 1,* email, Qingsu Xia 2 , Jian Yan 1 , Diogenes Herreno-Saenz 3 , Yuh-Shen Wu 4 , I-Wah Tang 2  and Peter P. Fu 2,* email
1 Department of Chemistry, Jackson State University, Jackson, MS 39217, USA 2 National Center for Toxicological Research, Jefferson, AR 72079, USA 3 Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico 00935 4 Hung Kuang University, Sha-Lu, Taichung, Taiwan, ROC
* Authors to whom correspondence should be addressed.
Received: 12 July 2005; in revised form: 20 January 1995 / Accepted: 1 August 2006 / Published: 31 December 2006
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Abstract: Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which PAHs induce genotoxicity. Although the metabolic activation of PAHs leading to biological activities has been well studied, the photo-induced activation pathway has seldom reported. In this paper, we review the study of photoirradiation of PAHs with UVA irradiation results in (i) cytotoxicity and DNA damage (ii) DNA single strand cleavage; (iii) formation of 8-hydroxy-2’-deoxyguanosine adduct (8-OHdG), and (iv) formation of lipid peroxidation. Evidence has been shown that these photobiological activities are mediated by reactive oxygen species (ROS).
Keywords: Polycyclic aromatic hydrocarbons (PAHs); photoirradiation; lipid peroxidation; DNA damage; 8-OHdG

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Cite This Article

MDPI and ACS Style

Yu, H.; Xia, Q.; Yan, J.; Herreno-Saenz, D.; Wu, Y.-S.; Tang, I.-W.; Fu, P.P. Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage. Int. J. Environ. Res. Public Health 2006, 3, 348-354.

AMA Style

Yu H, Xia Q, Yan J, Herreno-Saenz D, Wu Y-S, Tang I-W, Fu PP. Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage. International Journal of Environmental Research and Public Health. 2006; 3(4):348-354.

Chicago/Turabian Style

Yu, Hongtao; Xia, Qingsu; Yan, Jian; Herreno-Saenz, Diogenes; Wu, Yuh-Shen; Tang, I-Wah; Fu, Peter P. 2006. "Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage." Int. J. Environ. Res. Public Health 3, no. 4: 348-354.

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