Association between Multi-level Inorganic Arsenic Exposure from Drinking Water and Skin Lesions in China
Abstract
:Introduction
Methods
Study Population
Interviews and Skin Examination
Water Sample Collection
Statistical Analyses
Results
Discussion
Conclusion
Subjects | Arsenic-affected village n = 109 | Control village n = 32 |
---|---|---|
Sex (%) | ||
Male | 59 (54.1) | 16 (50.0) |
Female | 50 (45.9) | 16 (50.0) |
Age in years (mean SD*) | 43.1 (13.4) | 42.1 (10.1) |
Smoker (%) | ||
Never smoked | 59 (54.1) | 15 (46.9) |
Current smoked | 50 (45.9) | 17 (53.1) |
Arsenic exposure levels (mean (SD)) | 150.2 (36.0) | 5.4 (5.1) |
Range of arsenic exposed (μg/liter) | 2.3–197.3 | 1–18.7 |
No. of years of using well (mean SD*) | 14.1 (7.1) | 11.8 (7.0) |
Age group | Arsenic-affected village | Control village | ||||
---|---|---|---|---|---|---|
No. of subjects | Skin lesions | No. of subjects | Skin lesions | |||
No. of case | Prevalence (%) | No. of case | Prevalence (%) | |||
Male | ||||||
18–29 | 9 | 1 | 11.1 | 1 | 0 | 0.0 |
30–39 | 13 | 6 | 46.2 | 6 | 1 | 16.7 |
40–49 | 21 | 16 | 76.2 | 4 | 0 | 0.0 |
50–59 | 9 | 7 | 77.8 | 4 | 0 | 0.0 |
60- | 7 | 4 | 57.1 | 1 | 0 | 0.0 |
Total | 59 | 34 | 57.6 | 16 | 1 | 6.3 |
Female | ||||||
18–29 | 8 | 1 | 12.5 | 1 | 0 | 0.0 |
30–39 | 15 | 8 | 53.3 | 8 | 2 | 25.0 |
40–49 | 15 | 8 | 53.3 | 3 | 0 | 0.0 |
50–59 | 6 | 4 | 66.7 | 4 | 0 | 0.0 |
60- | 6 | 1 | 16.7 | 0 | 0 | 0.0 |
Total | 50 | 22 | 44.0 | 16 | 2 | 12.5 |
Both sexes | ||||||
18–29 | 17 | 2 | 11.8 | 2 | 0 | 0.0 |
30–39 | 28 | 14 | 50.0 | 14 | 3 | 21.4 |
40–49 | 36 | 24 | 66.7 | 7 | 0 | 0.0 |
50–59 | 15 | 11 | 73.3 | 8 | 0 | 0.0 |
60- | 13 | 5 | 38.5 | 1 | 0 | 0.0 |
Total | 109 | 56 | 51.4 | 32 | 3 | 9.4 |
Subjects | No. of subjects | Prevalence of skin lesions % | OR* | 95% CI* | P |
---|---|---|---|---|---|
Village | |||||
Control village | 32 | 9.4 | 1.00 | ||
Arsenic affected village | 109 | 51.4 | 10.21 | 2.68, 38.97 | 0.000 |
Sex | |||||
Male | 75 | 46.7 | 1.00 | ||
Female | 66 | 36.4 | 0.65 | 0.33, 1.29 | 0.217 |
Smoking | |||||
Never | 74 | 45.9 | 1.00 | ||
Current | 67 | 37.3 | 0.70 | 0.36, 1.38 | 0.301 |
Drinking | |||||
No | 89 | 40.4 | 1.00 | ||
Yes | 51 | 43.1 | 2.45 | 0.80, 7.49 | 0.103 |
Levels of arsenic in well | |||||
As≦50μg/l | 35 | 11.4 | 1.00 | ||
51–99μg/l | 6 | 33.3 | 3.88 | 0.49, 30.59 | 0.166 |
100–149μg/l | 30 | 46.7 | 6.78 | 1.70, 27.10 | 0.001 |
150μg/l< | 70 | 55.7 | 9.75 | 2.74, 34.67 | 0.000 |
Duration of exposure | |||||
1–5 years | 31 | 22.6 | 1.00 | ||
6–15 years | 41 | 43.9 | 2.68 | 0.91, 7.88 | 0.062 |
15< years | 69 | 49.3 | 3.33 | 1.22, 9.07 | 0.013 |
Levels/Exposure | No. of skin lesions | Adjusted OR*a,b | 95% CI | P | P for trend |
---|---|---|---|---|---|
Levels of arsenic in wella | |||||
As≦50μg/l | 4 | 1.00 | |||
51–99μg/l | 2 | 15.50 | 1.53, 248.70 | 0.022 | |
100–149μg/l | 14 | 16.10 | 3.73, 69.63 | 0.000 | |
150μg/l< | 39 | 25.70 | 6.43, 102.87 | 0.000 | 0.000 |
Duration of exposureb | |||||
1–5 | 7 | 1.00 | |||
6–15 | 18 | 1.68 | 0.40, 6.91 | 0.471 | |
15< | 34 | 2.30 | 0.58, 9.14 | 0.236 | 0.119 |
Acknowledgment
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Guo, X.; Fujino, Y.; Ye, X.; Liu, J.; Yoshimura, T. Association between Multi-level Inorganic Arsenic Exposure from Drinking Water and Skin Lesions in China. Int. J. Environ. Res. Public Health 2006, 3, 262-267. https://doi.org/10.3390/ijerph2006030031
Guo X, Fujino Y, Ye X, Liu J, Yoshimura T. Association between Multi-level Inorganic Arsenic Exposure from Drinking Water and Skin Lesions in China. International Journal of Environmental Research and Public Health. 2006; 3(3):262-267. https://doi.org/10.3390/ijerph2006030031
Chicago/Turabian StyleGuo, Xiaojuan, Yoshihisa Fujino, Xiaolei Ye, Jun Liu, and Takesumi Yoshimura. 2006. "Association between Multi-level Inorganic Arsenic Exposure from Drinking Water and Skin Lesions in China" International Journal of Environmental Research and Public Health 3, no. 3: 262-267. https://doi.org/10.3390/ijerph2006030031