Next Article in Journal
Worldwide Regulations of Standard Values of Pesticides for Human Health Risk Control: A Review
Next Article in Special Issue
Diurnal Temperature Range in Relation to Daily Mortality and Years of Life Lost in Wuhan, China
Previous Article in Journal
Effect of Patulin from Penicillium vulpinum on the Activity of Glutathione-S-Transferase and Selected Antioxidative Enzymes in Maize
Previous Article in Special Issue
Development and Validation of a Behavioural Index for Adaptation to High Summer Temperatures among Urban Dwellers
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2017, 14(7), 827; doi:10.3390/ijerph14070827

Increased Risk of Drug-Induced Hyponatremia during High Temperatures

1
Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping 587 58, Sweden
2
Department of Clinical Pharmacology, Department of Medical and Health Sciences, Linköping University, Linköping 581 85, Sweden
3
Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå 901 85, Sweden
4
Department of Endocrinology, Department of Medical and Health Sciences, Linköping University, Linköping, 581 85, Sweden
5
Institute of Public Health, Heidelberg University, Heidelberg, 691 20, Germany
*
Author to whom correspondence should be addressed.
Received: 2 May 2017 / Revised: 17 July 2017 / Accepted: 18 July 2017 / Published: 22 July 2017
(This article belongs to the Special Issue Climate Change and Human Health)
View Full-Text   |   Download PDF [712 KB, uploaded 24 July 2017]   |  

Abstract

Purpose: To investigate the relationship between outdoor temperature in Sweden and the reporting of drug-induced hyponatremia to the Medical Products Agency (MPA). Methods: All individual adverse drug reactions (ADR) reported to MPA from 1 January 2010 to 31 October 2013 of suspected drug-induced hyponatremia and random controls were identified. Reports where the ADR had been assessed as having at least a possible relation to the suspected drug were included. Information on administered drugs, onset date, causality assessment, sodium levels, and the geographical origin of the reports was extracted. A case-crossover design was used to ascertain the association between heat exposure and drug-induced hyponatremia at the individual level, while linear regression was used to study its relationship to sodium concentration in blood. Temperature exposure data were obtained from the nearest observation station to the reported cases. Results: During the study period, 280 reports of hyponatremia were identified. More cases of drug-induced hyponatremia were reported in the warmer season, with a peak in June, while other ADRs showed an opposite annual pattern. The distributed lag non-linear model indicated an increasing odds ratio (OR) with increasing temperature in the warm season with a highest odds ratio, with delays of 1–5 days after heat exposure. A cumulative OR for a lag time of 1 to 3 days was estimated at 2.21 at an average daily temperature of 20 °C. The change in sodium per 1 °C increase in temperature was estimated to be −0.37 mmol/L (95% CI: −0.02, −0.72). Conclusions: Warm weather appears to increase the risk of drug-induced hyponatremia View Full-Text
Keywords: average daily temperature; hyponatremia; adverse drug reaction average daily temperature; hyponatremia; adverse drug reaction
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jönsson, A.K.; Lövborg, H.; Lohr, W.; Ekman, B.; Rocklöv, J. Increased Risk of Drug-Induced Hyponatremia during High Temperatures. Int. J. Environ. Res. Public Health 2017, 14, 827.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top