Next Article in Journal
Identification of a Blue Zone in a Typical Chinese Longevity Region
Previous Article in Journal
Geographical Environment Factors and Risk Assessment of Tick-Borne Encephalitis in Hulunbuir, Northeastern China
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2017, 14(6), 570; doi:10.3390/ijerph14060570

The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment

1
Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, 420/1 Rajvithi Road, Bangkok 10400, Thailand
2
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
3
Department of Psychology, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA
4
Sawanpracharak Hospital, 43 Autakavee Road, Paknumpo, Muang, Nakhon Sawan 60000, Thailand
5
Paholpolpayuhasena Hospital, 572 Sangchuto Road, Ban Tai, Kanchanaburi 71000, Thailand
6
Amnatcharoen Hospital, 291 Arunprasert Road, Muang, Amnatcharoen 37000, Thailand
7
College of Health Sciences, University of Massachusetts Lowell, One University Ave, Lowell, MA 01854-2867, USA
*
Author to whom correspondence should be addressed.
Academic Editor: José G. Dórea
Received: 17 March 2017 / Revised: 14 May 2017 / Accepted: 25 May 2017 / Published: 27 May 2017
(This article belongs to the Section Environmental Health)
View Full-Text   |   Download PDF [684 KB, uploaded 27 May 2017]   |  

Abstract

A birth cohort was begun to investigate the levels and sources of pesticide exposure in pregnant women living in Thailand, and to examine the effects of pesticide exposure on infant neurodevelopment at five months of age. Subjects were interviewed using questionnaires regarding their demographic characteristics, educational background, and work and home activities related to pesticide exposures. Spot urine samples were collected at 28 weeks gestation and analyzed by gas chromatography-mass spectrometry to determine maternal metabolite levels of organophosphate pesticides including dimethyl phosphate (DMP); total DEP (diethyl phosphate (DEP), diethyl thiophosphate (DETP), and diethyl dithiophosphate (DEDTP), and total DAP (the sum of all metabolite levels). At five months of age, infant development was evaluated using the Bayley Scales of Infant and Toddler Development-III (Bayley-III). Higher total DEP and total DAP metabolite levels from the mother at 28 weeks’ gestation were significantly associated with reduced motor composite scores on the Bayley-III at five months of age. The total DEP levels were also significantly associated with reduced cognitive composite scores. Prenatal concentrations of maternal urinary metabolites were associated with infant cognitive and motor development. The results of several studies now suggest the need for public health intervention to reduce prenatal pesticide exposures from both agricultural and domestic use. View Full-Text
Keywords: organophosphate metabolites; pregnant women; infant neurodevelopment; Bayley Scales of Infant and Toddler Development organophosphate metabolites; pregnant women; infant neurodevelopment; Bayley Scales of Infant and Toddler Development
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kongtip, P.; Techasaensiri, B.; Nankongnab, N.; Adams, J.; Phamonphon, A.; Surach, A.; Sangprasert, S.; Thongsuksai, A.; Srikumpol, P.; Woskie, S. The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment. Int. J. Environ. Res. Public Health 2017, 14, 570.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top