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Int. J. Environ. Res. Public Health 2017, 14(3), 232; doi:10.3390/ijerph14030232

Toxicity Research of PM2.5 Compositions In Vitro

2
,
2
and
1,*
1
Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, China
2
Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 9 December 2016 / Revised: 10 February 2017 / Accepted: 23 February 2017 / Published: 26 February 2017
(This article belongs to the Section Environmental Health)
View Full-Text   |   Download PDF [332 KB, uploaded 28 February 2017]

Abstract

According to the published literature, we surmise that particulate matter (PM) concentration, individually, may be less important than components in explaining health effects. PM2.5 (aerodynamic diameter <2.5 μm) had similar cytotoxicity (e.g., cell viability reduction, oxidative damage, inflammatory effects and genetic toxicity) on different types of cells. The studies of cells are readily available for detailed mechanistic investigations, which is more appropriate for learning and comparing the mechanism caused by single or mixed ingredients coating a carbon core. No review exists that holistically examines the evidence from all components-based in vitro studies. We reviewed published studies that focus on the cytotoxicity of normal PM2.5. Those studies suggested that the toxicity of mixed compositions differs greatly from the single ingredients in mixed components and the target cells. The cytotoxic responses caused by PM2.5 components have not shown a consistent association with clear, specific health effects. The results may be beneficial for providing new targets for drugs for the treatment of PM2.5-related diseases. View Full-Text
Keywords: cell; particular matter; components; toxicology; health cell; particular matter; components; toxicology; health
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jia, Y.-Y.; Wang, Q.; Liu, T. Toxicity Research of PM2.5 Compositions In Vitro. Int. J. Environ. Res. Public Health 2017, 14, 232.

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