Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis
AbstractAn inverse association has been reported between coffee consumption and the risk of several cancers. However, the association between coffee and thyroid cancer is controversial. Thus, this study aimed to evaluate the association between coffee consumption and the risk of thyroid cancer through a systematic review and meta-analysis. Published studies were examined from PubMed, Embase, Cochrane Central, and the reference lists of the retrieved articles. The summary odds ratio (OR) for the association between coffee consumption was categorized as highest versus lowest consumption, and thyroid cancer risk was calculated using a fixed effects model. Subgroup analyses by study design, geographic location, source of controls, and adjusted variables were performed. A total of 1039 thyroid cancer cases and 220,816 controls were identified from five case-control studies and two cohort studies. The summary OR for the association between coffee consumption and thyroid cancer risk was 0.88 (95% confidence interval (CI) = 0.71–1.07). There was no significant heterogeneity among the study results (I² = 0%, p = 0.79). However, the beneficial effect of coffee consumption on thyroid cancer was found only in hospital-based case-control studies (OR= 0.59, 95% CI= 0.37–0.93). There was no significant association between coffee consumption and thyroid cancer risk according to our meta-analysis results. These findings should be interpreted with caution because of potential biases and confounding variables. Further prospective studies with a larger number of cases are encouraged to confirm these results. View Full-Text
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Han, M.A.; Kim, J.H. Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2017, 14, 129.
Han MA, Kim JH. Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2017; 14(2):129.Chicago/Turabian Style
Han, Mi A.; Kim, Jin H. 2017. "Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis." Int. J. Environ. Res. Public Health 14, no. 2: 129.
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