Effects of Weight Loss on Advanced Glycation End Products in Subjects with and without Diabetes: A Preliminary Report
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Biochemical Analysis
2.3. CML Analysis
2.3.1. Sample Preparation
2.3.2. CML Quantification Using RP-HPLC
2.4. Statistics
3. Results
3.1. The Effect of Weight Loss on Biochemical Characteristics and CML Levels
3.2. Correlation Analysis
4. Discussion
5. Conclusions
Author Contributions
Conflicts of Interest
References
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Parameters | n | Before Weight Loss | After Weight Loss | p-Value |
---|---|---|---|---|
TC (mmol/L) | 39 | 4.9 ± 0.9 | 4.5 ± 0.9 | <0.01 |
TG (mmol/L) | 39 | 1.8 ± 0.8 | 1.4 ± 0.6 | <0.001 |
HDL-cholesterol (mmol/L) | 39 | 1.2 ± 0.3 | 1.3 ± 0.3 | >0.05 |
LDL-cholesterol (mmol/L) | 39 | 2.9 ± 0.8 | 2.7 ± 0.8 | >0.05 |
Glucose (mmol/L) | 41 | 6.8 ± 1.7 | 6.3 ± 1.1 | <0.05 |
HbA1c (%) | 29 | 6.8 ± 0.7 | 6.2 ± 0.5 | <0.001 |
CML (mmol CML/mol Lys) | 49 | 0.070 ± 0.017 | 0.060 ± 0.009 | <0.001 |
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Deo, P.; Keogh, J.B.; Price, N.J.; Clifton, P.M. Effects of Weight Loss on Advanced Glycation End Products in Subjects with and without Diabetes: A Preliminary Report. Int. J. Environ. Res. Public Health 2017, 14, 1553. https://doi.org/10.3390/ijerph14121553
Deo P, Keogh JB, Price NJ, Clifton PM. Effects of Weight Loss on Advanced Glycation End Products in Subjects with and without Diabetes: A Preliminary Report. International Journal of Environmental Research and Public Health. 2017; 14(12):1553. https://doi.org/10.3390/ijerph14121553
Chicago/Turabian StyleDeo, Permal, Jennifer B. Keogh, Naomi J. Price, and Peter M. Clifton. 2017. "Effects of Weight Loss on Advanced Glycation End Products in Subjects with and without Diabetes: A Preliminary Report" International Journal of Environmental Research and Public Health 14, no. 12: 1553. https://doi.org/10.3390/ijerph14121553