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Int. J. Environ. Res. Public Health 2017, 14(1), 90; doi:10.3390/ijerph14010090

Transcriptome Profiling of the Lungs Reveals Molecular Clock Genes Expression Changes after Chronic Exposure to Ambient Air Particles

College of Environmental Science and Engineering, Dong Hua University, Shanghai 201620, China
Laboratory of Environmental Criteria and Risk Assessment & Environmental Standards Institute, Chinese Research Academy of Environmental Sciences, Beijing 100012, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 28 September 2016 / Revised: 10 January 2017 / Accepted: 13 January 2017 / Published: 18 January 2017
(This article belongs to the Section Environmental Health)
View Full-Text   |   Download PDF [3135 KB, uploaded 18 January 2017]   |  


The symptoms of asthma, breathlessness, insomnia, etc. all have relevance to pulmonary rhythmic disturbances. Epidemiology and toxicology studies have demonstrated that exposure to ambient air particles can result in pulmonary dysfunction. However, there are no data directly supporting a link between air pollution and circadian rhythm disorder. In the present study, we found that breathing highly polluted air resulted in changes of the molecular clock genes expression in lung by transcriptome profiling analyses in a rodent model. Compared to those exposed to filtered air, in both pregnant and offspring rats in the unfiltered group, key clock genes (Per1, Per2, Per3, Rev-erbα and Dbp) expression level decreased and Bmal1 expression level increased. In both rat dams and their offspring, after continuous exposure to unfiltered air, we observed significant histologic evidence for both perivascular and peribronchial inflammation, increased tissue and systemic oxidative stress in the lungs. Our results suggest that chronic exposure to particulate matter can induce alterations of clock genes expression, which could be another important pathway for explaining the feedbacks of ambient particle exposure in addition to oxidative stress and inflammation. View Full-Text
Keywords: ambient air particles; transcriptome; lung; rhythm; clock genes ambient air particles; transcriptome; lung; rhythm; clock genes

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Song, P.; Li, Z.; Li, X.; Yang, L.; Zhang, L.; Li, N.; Guo, C.; Lu, S.; Wei, Y. Transcriptome Profiling of the Lungs Reveals Molecular Clock Genes Expression Changes after Chronic Exposure to Ambient Air Particles. Int. J. Environ. Res. Public Health 2017, 14, 90.

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