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Int. J. Environ. Res. Public Health 2016, 13(9), 892; doi:10.3390/ijerph13090892

Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer

1
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
2
Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China
3
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China
4
Institute of Hospital Pharmacy, Central South University, Changsha 410008, China
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 29 July 2016 / Revised: 1 September 2016 / Accepted: 5 September 2016 / Published: 8 September 2016
View Full-Text   |   Download PDF [325 KB, uploaded 8 September 2016]

Abstract

Colorectal cancer (CRC) represents the third most common type of cancer in developed countries and one of the leading causes of cancer deaths worldwide. Personalized management of CRC has gained increasing attention since there are large inter-individual variations in the prognosis and response to drugs used to treat CRC owing to molecular heterogeneity. Approximately 15% of CRCs are caused by deficient mismatch repair (dMMR) characterized by microsatellite instability (MSI) phenotype. The present review is aimed at highlighting the role of MMR status in informing prognosis and personalized treatment of CRC including adjuvant chemotherapy, targeted therapy, and immune checkpoint inhibitor therapy to guide the individualized therapy of CRC. View Full-Text
Keywords: colorectal cancer; personalized treatment; mismatch repair system; microsatellite instability; adjuvant chemotherapy; targeted therapy; immune checkpoint inhibitor therapy colorectal cancer; personalized treatment; mismatch repair system; microsatellite instability; adjuvant chemotherapy; targeted therapy; immune checkpoint inhibitor therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhang, C.-M.; Lv, J.-F.; Gong, L.; Yu, L.-Y.; Chen, X.-P.; Zhou, H.-H.; Fan, L. Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer. Int. J. Environ. Res. Public Health 2016, 13, 892.

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