Next Article in Journal
Working with Climate Projections to Estimate Disease Burden: Perspectives from Public Health
Previous Article in Journal
Comparison of the Combined Obesity Indices to Predict Cardiovascular Diseases Risk Factors and Metabolic Syndrome in Northeast China
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2016, 13(8), 800; doi:10.3390/ijerph13080800

Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study

1
Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
2
Department of Hygiene, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
3
Environment Preservation Center, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
4
Respiratory Medicine, Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
5
Respiratory Medicine, National Hospital Organization Nanao Hospital, 3-1 Mattou-machi Yabe, Nanao, Ishikawa 926-8531, Japan
6
Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 5 May 2016 / Revised: 3 August 2016 / Accepted: 4 August 2016 / Published: 9 August 2016
View Full-Text   |   Download PDF [935 KB, uploaded 9 August 2016]   |  

Abstract

Information on potential cough triggers including environmental irritants is vital for successful management of chronic cough in patients. We investigated the relationship between ambient levels of particulate polycyclic aromatic hydrocarbons (PAH), nitrogen dioxide (NO2) and sulphur dioxide (SO2) exposures with cough prevalence. Eighty-three adult patients, who had been physician diagnosed with at least asthma, cough variant asthma and/or atopic cough, were divided into asthma and non-asthma groups. They recorded daily cough symptoms during 4 January–30 June 2011 study period while daily samples of total suspended particles were simultaneously collected by use of glass fiber filters and the particulate PAH content determined by high performance liquid chromatography coupled with a fluorescence detector. Ambient concentrations of NO2 and SO2 were obtained from a local monitoring site. Logistic regression models using generalized estimating equations were used to determine population-averaged estimates of association between cough prevalence and ambient pollutant exposures for the two groups. Fully adjusted odds ratios from single pollutant models were 1.083 (95% confidence interval (CI): 1.029, 1.140) and 1.097 (95% CI: 1.016, 1.185) per 0.57 ng/m3 for lag2 PAH exposure, while only for asthma group had significant associations with NO2 and SO2 exposures for both lag2 and lag02. Similar associations were observed in multipollutant models. This finding suggests that ambient PAH, NO2, and SO2 exposure even at low levels is related to cough prevalence in adult chronic cough patients and may be considered as aggravating factor during clinical management of the condition. View Full-Text
Keywords: polycyclic aromatic hydrocarbon; adult patients; asthma; generalized estimating equation; total suspended particles; chronic cough polycyclic aromatic hydrocarbon; adult patients; asthma; generalized estimating equation; total suspended particles; chronic cough
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Anyenda, E.O.; Higashi, T.; Kambayashi, Y.; Nguyen, T.T.T.; Michigami, Y.; Fujimura, M.; Hara, J.; Tsujiguchi, H.; Kitaoka, M.; Asakura, H.; Hori, D.; Yamada, Y.; Hayashi, K.; Hayakawa, K.; Nakamura, H. Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study. Int. J. Environ. Res. Public Health 2016, 13, 800.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top