Assessing a New Method for Measuring Fetal Exposure to Mercury: Newborn Bloodspots
AbstractBackground: Measuring mercury in newborn bloodspots to determine fetal exposures is a novel methodology with many advantages. Questions remain, however, about its reliability as an estimate of newborn exposure to mercury. Methods: We studied mercury concentrations in paired bloodspots and cord blood from a convenience sample of 48 Minnesota women and infants. Results: The limit of detection for bloodspots was higher than for cord blood (0.7 and 0.3 μg/L in bloodspots and cord blood, respectively) with the result that mercury was detected in only 38% of newborn bloodspots compared to 62% of cord blood samples. The geometric mean mercury concentration in cord blood was 0.6 μg/L. Mercury concentrations were almost uniformly lower in bloodspots than in cord blood (mean ratio (±SD) = 0.85 ± 0.4), their mean value was significantly less than that for the cord blood (p = 0.02), and the two methods were highly correlated (r = 0.82). Conclusion: These preliminary findings indicate that newborn bloodspot mercury measurements have utility; however, until bloodspot analyses are more sensitive, they are likely to underestimate in utero exposure. View Full-Text
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Nelson, J.W.; Edhlund, B.L.; Johnson, J.; Rosebush, C.E.; Holmquist, Z.S.; Swan, S.H.; Nguyen, R.H.N. Assessing a New Method for Measuring Fetal Exposure to Mercury: Newborn Bloodspots. Int. J. Environ. Res. Public Health 2016, 13, 692.
Nelson JW, Edhlund BL, Johnson J, Rosebush CE, Holmquist ZS, Swan SH, Nguyen RHN. Assessing a New Method for Measuring Fetal Exposure to Mercury: Newborn Bloodspots. International Journal of Environmental Research and Public Health. 2016; 13(7):692.Chicago/Turabian Style
Nelson, Jessica W.; Edhlund, Betsy L.; Johnson, Jean; Rosebush, Christina E.; Holmquist, Zachary S.; Swan, Shanna H.; Nguyen, Ruby H.N. 2016. "Assessing a New Method for Measuring Fetal Exposure to Mercury: Newborn Bloodspots." Int. J. Environ. Res. Public Health 13, no. 7: 692.
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