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Int. J. Environ. Res. Public Health 2016, 13(6), 559; doi:10.3390/ijerph13060559

Incidence and Mortality Risks of Cancer in Patients with Type 2 Diabetes: A Retrospective Study in Shanghai, China

1
Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong 226001, China
2
Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
3
Shanghai Diabetes Institute, Shanghai 200233, China
4
Shanghai Clinical Centre of Diabetes, Shanghai 200233, China
5
Department of Cancer Prevention and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200233, China
6
Department of Vital Statistics, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200233, China
7
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
8
Vice-Director of the Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200233, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 19 March 2016 / Revised: 1 May 2016 / Accepted: 25 May 2016 / Published: 3 June 2016
View Full-Text   |   Download PDF [290 KB, uploaded 3 June 2016]

Abstract

Background: Evidence from epidemiologic investigation indicates that people with type 2 diabetes (T2DM) are at a significantly higher risk of many types of cancer and mortality. The aim of this study was to investigate the incidence and mortality risks of cancer in patients with T2DM compared with the general population in Shanghai, China. Methods: Based on the Shanghai Diabetes Registry (SDR) database linking to the Shanghai Cancer Registry and Surveillance System (SCRSS), a total of 12,276 T2DM patients without cancer were defined and followed up from 1 December 2001 to 31 July 2011. Standardized incidence ratio (SIR) and standardized mortality ratio (SMR) with 95% confidence interval (CI) were calculated using the whole gender and age-matched general population of Shanghai as a reference during the same period. Results: The overall cancer risk was found higher in both males and females T2DM patients, with the SIR of 3.14 (95% CI 2.73–3.56) and 4.29 (95% CI 3.64–4.94), respectively. The overall mortality risk of cancer also significantly increased with the SMR of 2.27 (95% CI 1.86–2.68) and 1.86 (95% CI 1.46–2.26), respectively. Pancreatic cancer was with the highest SIR and SMR in both genders. Conclusions: Compared with the general population, patients with T2DM were associated with higher incidence and mortality risks of cancer, especially pancreatic cancer. View Full-Text
Keywords: type 2 diabetes; cancer; mortality; standardized incidence ratio; standardized mortality ratio type 2 diabetes; cancer; mortality; standardized incidence ratio; standardized mortality ratio
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gu, Y.; Hou, X.; Zheng, Y.; Wang, C.; Zhang, L.; Li, J.; Huang, Z.; Han, M.; Bao, Y.; Zhong, W.; Jia, W.; Cui, S. Incidence and Mortality Risks of Cancer in Patients with Type 2 Diabetes: A Retrospective Study in Shanghai, China. Int. J. Environ. Res. Public Health 2016, 13, 559.

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