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Int. J. Environ. Res. Public Health 2016, 13(6), 537; doi:10.3390/ijerph13060537

Residential Risk Factors for Atopic Dermatitis in 3- to 6-Year Old Children: A Cross-Sectional Study in Shanghai, China

Department of Dermatology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China
Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350000, China
Department of Dermatology, Jiading District Traditional Chinese Medicine Hospital, Shanghai 201800, China
School of Public Health, Key Lab of Public Health Safety of the Ministry of Education & Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China
Department of Medical Science, Occupational and Environmental Medicine, Uppsala University, Uppsala 75185, Sweden
These authors contributed equally to this study.
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 22 February 2016 / Revised: 20 April 2016 / Accepted: 19 May 2016 / Published: 27 May 2016
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Background: Atopic dermatitis (AD) is common among pre-school children in Shanghai. This study aimed to identify the risk factors for childhood AD from the perspectives of home environment, demographics and parents-grandparents’ atopic disease. Methods: A cross-sectional study was conducted in Shanghai in April–June, 2010. Preschool children’s parents or guardians were invited to participate a questionnaire survey in six districts (two urban and four suburban/rural) and 6624 children were finally recruited (51.3% boys). AD diagnosis was based on the U.K. Working Party’s (UKWP) criteria. Adjusted odds ratios (AOR) with 95% confidence intervals (95% CI) were calculated by multiple logistic regression. Results: A total of 8.5% of children ever had AD. Around 10.2% of the mothers had lived in newly renovated/decorated homes (NRDH) during the prenatal period (one year before or during pregnancy) and 9.5% got new home furniture (NHF) during the same period. AD was more common in children when mothers had lived in NRDH homes during the prenatal period (AOR = 1.41; 95% CI 1.03–1.93), the current home had indoor mold (2.00, 1.48–2.70), parents-grandparents’ had atopic diseases (3.85, 3.05–4.87), the children had food allergy (3.40, 2.63–4.40) or children lived in urban area (1.52, 1.18–1.96). Associations between AD and NRDH, NHF and indoor molds were only significant in children without parents-grandparents’ atopic diseases. There was an interaction effect between parents-grandparents’ atopic diseases and NRDH (p < 0.05). Conclusions: Home renovation/ redecoration, new furniture and indoor mold, urban residency, heredity disposition and food allergy can be risk factors for childhood AD in Shanghai. View Full-Text
Keywords: dermatology; home environment; redecoration; mold; dampness; urban residency; heredity dermatology; home environment; redecoration; mold; dampness; urban residency; heredity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xu, F.; Yan, S.; Zheng, Q.; Li, F.; Chai, W.; Wu, M.; Kan, H.; Norback, D.; Xu, J.; Zhao, Z. Residential Risk Factors for Atopic Dermatitis in 3- to 6-Year Old Children: A Cross-Sectional Study in Shanghai, China. Int. J. Environ. Res. Public Health 2016, 13, 537.

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