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Int. J. Environ. Res. Public Health 2016, 13(4), 399;

Effects of 20 Selected Fruits on Ethanol Metabolism: Potential Health Benefits and Harmful Impacts

Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
School of Chinese Medicine, The University of Hong Kong, Hong Kong, China
South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510006, Guangdong Province, China
Author to whom correspondence should be addressed.
Academic Editors: Amie Hayley and Joris Cornelis Verster
Received: 16 February 2016 / Revised: 28 March 2016 / Accepted: 30 March 2016 / Published: 1 April 2016
(This article belongs to the Special Issue Advances in Substance and Drug Abuse Prevention)
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The consumption of alcohol is often accompanied by other foods, such as fruits and vegetables. This study is aimed to investigate the effects of 20 selected fruits on ethanol metabolism to find out their potential health benefits and harmful impacts. The effects of the fruits on ethanol metabolism were characterized by the concentrations of ethanol and acetaldehyde in blood, as well as activities of alcohol dehydrogenase and acetaldehyde dehydrogenase in liver of mice. Furthermore, potential health benefits and harmful impacts of the fruits were evaluated by biochemical parameters including aspartate transaminase (AST), alanine transferase (ALT), malondialdehyde, and superoxide dismutase. Generally, effects of these fruits on ethanol metabolism were very different. Some fruits (such as Citrus limon (yellow), Averrhoa carambola, Pyrus spp., and Syzygium samarangense) could decrease the concentration of ethanol in blood. In addition, several fruits (such as Cucumis melo) showed hepatoprotective effects by significantly decreasing AST or ALT level in blood, while some fruits (such as Averrhoa carambola) showed adverse effects. The results suggested that the consumption of alcohol should not be accompanied by some fruits, and several fruits could be developed as functional foods for the prevention and treatment of hangover and alcohol use disorder. View Full-Text
Keywords: alcohol; metabolism; fruit; hepatoprotection; harmful impact alcohol; metabolism; fruit; hepatoprotection; harmful impact

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Zhang, Y.-J.; Wang, F.; Zhou, Y.; Li, Y.; Zhou, T.; Zheng, J.; Zhang, J.-J.; Li, S.; Xu, D.-P.; Li, H.-B. Effects of 20 Selected Fruits on Ethanol Metabolism: Potential Health Benefits and Harmful Impacts. Int. J. Environ. Res. Public Health 2016, 13, 399.

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