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Int. J. Environ. Res. Public Health 2016, 13(12), 1243; doi:10.3390/ijerph13121243

Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes

1
Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China
2
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
3
Division of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China
4
Brain Disease Center, Tianjin Dagang Oil Field General Hospital, Tianjin 300280, China
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 16 October 2016 / Revised: 1 December 2016 / Accepted: 2 December 2016 / Published: 15 December 2016
(This article belongs to the Section Global Health)
View Full-Text   |   Download PDF [301 KB, uploaded 15 December 2016]

Abstract

Although both methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms have been associated with type 2 diabetes (T2D), their interactions with being overweight/obesity on T2D risk remain unclear. To evaluate the associations of the two polymorphisms with T2D and their interactions with being overweight/obesity on T2D risk, a case-control study of 180 T2D patients and 350 healthy controls was conducted in northern China. Additive interaction was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S). After adjustments for age and gender, borderline significant associations of the MTHFR C677T and MTRR A66G polymorphisms with T2D were observed under recessive (OR = 1.43, 95% CI: 0.98–2.10) and dominant (OR = 1.43, 95% CI: 1.00–2.06) models, respectively. There was a significant interaction between the MTHFR 677TT genotype and being overweight/obesity on T2D risk (AP = 0.404, 95% CI: 0.047–0.761), in addition to the MTRR 66AG/GG genotypes (RERI = 1.703, 95% CI: 0.401–3.004; AP = 0.528, 95% CI: 0.223–0.834). Our findings suggest that individuals with the MTHFR 677TT or MTRR 66AG/GG genotypes are more susceptible to the detrimental effect of being overweight/obesity on T2D. Further large-scale studies are still needed to confirm our findings. View Full-Text
Keywords: MTHFR C677T; MTRR A66G; overweight; obesity; type 2 diabetes; additive interaction MTHFR C677T; MTRR A66G; overweight; obesity; type 2 diabetes; additive interaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhi, X.; Yang, B.; Fan, S.; Li, Y.; He, M.; Wang, D.; Wang, Y.; Wei, J.; Zheng, Q.; Sun, G. Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes. Int. J. Environ. Res. Public Health 2016, 13, 1243.

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