Next Article in Journal
Predicting Driver Behavior during the Yellow Interval Using Video Surveillance
Previous Article in Journal
Decreases in Smoking-Related Cancer Mortality Rates Are Associated with Birth Cohort Effects in Korean Men
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2016, 13(12), 1212; doi:10.3390/ijerph13121212

Oxidative Stress and Genotoxicity of Long-Term Occupational Exposure to Low Levels of BTEX in Gas Station Workers

1
Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China
2
Research Center for Regenerative Medicine, Guangxi Medical University, Nanning 530021, China
3
Atmospheric Environment Research Center, Scientific Research Academy of Guangxi Environmental Protection, Nanning 530021, China
4
Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China
5
Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China
6
Center for Environmental Health Research, South China Institute of Environmental Sciences, Ministry of Environmental Protection, Guangzhou 510655, China
7
Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 6 September 2016 / Revised: 13 November 2016 / Accepted: 17 November 2016 / Published: 6 December 2016
View Full-Text   |   Download PDF [290 KB, uploaded 6 December 2016]

Abstract

Atmospheric benzene, toluene, ethylbenzene, and xylenes (BTEX) can lead to multiple health injuries. However, what remains uncertain is the effect of long-term exposure to low levels of BTEX. Thus, we determined the BTEX levels in the air from the refueling and office areas in gas stations. Then we collected workers’ (200 refueling vs. 52 office workers) peripheral blood samples to analyze the serum total-superoxide dismutase (T-SOD), glutathione (GSH), malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) levels. DNA damage was analyzed by the comet assay and micronucleus test in buccal epithelial cells. We found that the levels of BTEX in refueling areas were significantly higher than those in office areas (p < 0.001). The serum T-SOD and GSH of refueling workers were significantly lower than those in office workers (p < 0.001). By contrast, the serum MDA and 8-OHdG of refueling workers were significantly higher than those of office workers (p < 0.001, MDA; p = 0.025, 8-OHdG). Furthermore, tail and Olive tail moments in refueling workers were longer (p = 0.004, tail moment; p = 0.001, Olive tail moment), and the micronucleus rate was higher (p < 0.001) than those in office workers. Taken together, long-term exposure to low levels of BTEX may reduce the antioxidant ability and increase the risk of DNA damage in refueling workers of gas stations. View Full-Text
Keywords: antioxidant; BTEX; comet assay; DNA damage; micronucleus test; refueling workers antioxidant; BTEX; comet assay; DNA damage; micronucleus test; refueling workers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Xiong, F.; Li, Q.; Zhou, B.; Huang, J.; Liang, G.; Zhang, L.; Ma, S.; Qing, L.; Liang, L.; Su, J.; Peng, X.; Li, Q.; Zou, Y. Oxidative Stress and Genotoxicity of Long-Term Occupational Exposure to Low Levels of BTEX in Gas Station Workers. Int. J. Environ. Res. Public Health 2016, 13, 1212.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top