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Int. J. Environ. Res. Public Health 2016, 13(10), 965; doi:10.3390/ijerph13100965

Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas

1
Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Cheongju, Chungbuk 28644, Korea
2
Laboratory of Veterinary Biochemistry, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea
3
Laboratory of Veterinary Biotechnology and Embryology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Korea
4
Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Huixiao Hong
Received: 24 July 2016 / Revised: 14 September 2016 / Accepted: 23 September 2016 / Published: 28 September 2016
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Abstract

Octylphenol (OP) and bisphenol A (BPA) are known as endocrine-disrupting chemicals (EDCs). During pregnancy, the expression of steroid hormone receptors is controlled by maternal and fetal nutrition. To evaluate the impact of EDCs during pregnancy, ethinyl estradiol (EE, 0.2 mg/kg/day), OP (50 mg/kg/day), and BPA (50 mg/kg/day) were administered to pregnant mice. The mRNA levels of TRPV6 (transient receptor potential cation channels in subfamily V, member 6) decreased significantly by EE and OP. The PMCA1 (ATPase, Ca++ transporting, plasma membrane 1) mRNA and protein levels decreased significantly by EE, OP, and BPA. CTR1 (solute carrier family 31, member 1) and ATP7A (ATPase, Cu++ transporting, alpha polypeptide) expression decreased significantly by EE, OP, and BPA. The mRNA levels of IREG1 (iron-regulated transporter, member 1) decreased significantly by EE. Hephaestin (HEPH) mRNA levels decreased significantly by EE, OP, and BPA, and protein levels decreased significantly by BPA. As a result of immunohistochemistry analysis, all cation transporter proteins were found in labyrinth of placenta. To confirm the cytosolic level of cations, levels of cation level in fetal serum were measured. EE, OP, and BPA significantly reduced serum calcium and copper levels, and iron levels were reduced by BPA. Taken together, some EDCs, such as OP and BPA, could modulate the calcium, copper, and iron ion-transporting channels during pregnancy. The fetus relies on the mother for ionic transportation, and, therefore, pregnant women should avoid exposure to cation-channel-disrupting chemicals. View Full-Text
Keywords: endocrine-disrupting chemicals; octylphenol; bisphenol A; cation transport endocrine-disrupting chemicals; octylphenol; bisphenol A; cation transport
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MDPI and ACS Style

Lee, J.-H.; Ahn, C.; Kang, H.Y.; Hong, E.-J.; Hyun, S.-H.; Choi, K.-C.; Jeung, E.-B. Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas. Int. J. Environ. Res. Public Health 2016, 13, 965.

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