Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma
Abstract
:1. Introduction
2. Experimental Section
2.1. Statistical Analysis
2.2. Ethical Considerations
3. Results
Variables | Laryngeal Cancer Cases (n = 103) N (%) | Controls (n = 220) N (%) | p-Value a |
---|---|---|---|
Demographic characteristics | |||
Gender | |||
Male | 99 (96.12) | 211 (95.91) | |
Female | 4 (3.88) | 9 (4.09) | 1.000 |
Age | |||
<60 | 25 (24.27) | 64 (29.09) | |
≥60 | 78 (75.73) | 156 (70.91) | 0.366 |
Clinical stages | |||
0 | 2 (1.94) | ||
I | 30 (29.13) | ||
II | 38 (36.89) | ||
III | 27 (26.21) | ||
IV | 6 (5.83) | ||
Histological grades | |||
Low-differentiation | 26 (25.24) | ||
Moderate-differentiation | 40 (38.83) | ||
High-differentiation | 37 (35.92) | ||
Exposure Status | |||
Smoking status | |||
Never-smokers | 22 (21.36) | 108 (49.09) | |
Ever-smokers | 81 (78.64) | 112 (50.91) | <0.001 |
Alcohol consumption | |||
Never-drinkers | 36 (34.95) | 134 (60.91) | |
Ever-drinkers | 67 (65.05) | 86 (39.09) | <0.001 |
Genotype | Patients (n = 103) Number (%) | Controls (n = 220) Number (%) | OR (95% CI) a | p |
---|---|---|---|---|
rs4148323 | ||||
AA | 6 (5.8) | 29 (13.2) | 1.00 (reference) | |
AG | 21 (20.4) | 62 (28.2) | 1.142 (0.893–1.460) | 0.335 |
GG | 76 (73.8) | 129 (58.6) | 1.135 (1.032–1.249) | 0.022 * |
rs4148323 Allele | Patients (Gene Frequency) | Controls (Gene Frequency) | OR (95% CI) a | p | MAF [22] | |||
---|---|---|---|---|---|---|---|---|
EA or AA | KR | JP | HC | |||||
A | 0.16 | 0.27 | 1.00 (reference) | - | 0.172 | 0.106 | 0.223 | |
G | 0.84 | 0.73 | 1.149 (1.052–1.254) | 0.004 * |
Patients | AA Number (%) | AG+GG Number (%) | OR (95% CI) a | p |
---|---|---|---|---|
Histological grade | ||||
Moderate or low-differentiation | 3(4.6) | 63 (95.5) | 1.0 (reference) | |
High-differentiation | 3 (8.1) | 34 (91.9) | 1.039 (0.931–1.159) | 0.664 |
Clinical stage | ||||
0–II | 4 (5.7) | 66 (94.3) | 1.00 (reference) | |
III–IV | 2 (6.1) | 31 (93.9) | 1.004 (0.904–1.114) | 1.000 |
Variables | Patients/Control | AA | AG+GG | p | OR (95% CI) a |
---|---|---|---|---|---|
Smoking | |||||
Ever | 81/112 | 4/16 | 77/96 | 0.035 * | 1.109 (1.013–1.214) a |
Never | 22/108 | 2/13 | 20/95 | 1.000 | 1.033 (0.890–1.200) b |
Drinking | |||||
Ever | 67/86 | 2/14 | 65/72 | 0.008 ** | 1.159 (1.046–1.284) a |
Never | 36/134 | 4/15 | 32/119 | 1.000 | 1.001 (0.879–1.140) b |
Variables | Genotype | Patients | Control | OR (95% CI) | p |
---|---|---|---|---|---|
Smoking | |||||
Never | AA | 2 | 13 | 1.00 (reference) | |
Ever | AA | 4 | 16 | 1.208 (0.628–2.324) a | 0.680 |
Never | AG+GG | 20 | 95 | 1.00 (reference) | |
Ever | AG+GG | 77 | 96 | 1.579 (1.327–1.879) b | <0.001 |
Drinking | |||||
Never | AA | 4 | 15 | 1.00 (reference) | |
Ever | AA | 2 | 14 | 0.690 (0.210–2.276) a | 0.666 |
Never | AG+GG | 32 | 119 | 1.00 (reference) | |
Ever | AG+GG | 65 | 72 | 1.778 (1.413–2.237) b | <0.001 |
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Huangfu, H.; Pan, H.; Wang, B.; Wen, S.; Han, R.; Li, L. Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma. Int. J. Environ. Res. Public Health 2016, 13, 112. https://doi.org/10.3390/ijerph13010112
Huangfu H, Pan H, Wang B, Wen S, Han R, Li L. Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma. International Journal of Environmental Research and Public Health. 2016; 13(1):112. https://doi.org/10.3390/ijerph13010112
Chicago/Turabian StyleHuangfu, Hui, Hong Pan, Binquan Wang, Shuxin Wen, Rui Han, and Li Li. 2016. "Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma" International Journal of Environmental Research and Public Health 13, no. 1: 112. https://doi.org/10.3390/ijerph13010112