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Int. J. Environ. Res. Public Health 2015, 12(9), 11797-11814; doi:10.3390/ijerph120911797

Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China

1
Xinjiang Key Laboratory of Metabolic Disease Research, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China
2
Department of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830011, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Omorogieva Ojo
Received: 15 July 2015 / Revised: 30 August 2015 / Accepted: 6 September 2015 / Published: 18 September 2015
(This article belongs to the Collection Health Care and Diabetes)
View Full-Text   |   Download PDF [695 KB, uploaded 18 September 2015]

Abstract

Background: Genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene have been reported to be strongly associated with type 2 diabetes mellitus (T2DM) in Icelandic, Danish and American populations and further replicated in other European populations, African Americans, Mexican Americans, and Asian populations. The aim of the present study was to investigate the association of TCF7L2 gene polymorphisms with T2DM in a Uygur population of China. Methods: 877 T2DM patients and 871 controls were selected for the present study. Two single nucleotide polymorphisms (SNPs) (rs12255372 and rs7901695) were genotyped by using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. The associations of SNPs and haplotypes with T2DM and linkage disequilibrium (LD) structure of the TCF7L2 gene were analyzed. Results: For total participants and male, the distribution of rs12255372 alleles and the dominant model (Guanine Guanine (GG) genotype vs. Guanine Thymine (GT) genotype + Thymine Thymine (TT) genotype) showed significant difference between T2DM and control subjects (for allele: p = 0.013 and p = 0.002, respectively; for dominant model: p = 0.028 and p = 0.008, respectively). The distribution of rs7901695 alleles and the dominant model (TT genotype vs. Thymine Cytosine (TC) genotype + Cytosine Cytosine (CC) genotype) for total participants and male showed significant difference between T2DM and control subjects (for allele: both p = 0.001; for dominant model: p = 0.006 and p = 0.008, respectively). Conclusions: Our data suggested that the genetic polymorphisms of the TCF7L2 gene were associated with T2DM in the Uygur population of China. View Full-Text
Keywords: TCF7L2; Single nucleotide polymorphism; Type 2 diabetes mellitus; Case–control study TCF7L2; Single nucleotide polymorphism; Type 2 diabetes mellitus; Case–control study
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yao, H.; Wang, Z.; Wang, T.; Ma, Y.; Su, Y.; Ma, Q.; Wang, L.; Zhu, J. Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China. Int. J. Environ. Res. Public Health 2015, 12, 11797-11814.

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