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Int. J. Environ. Res. Public Health 2015, 12(8), 9054-9067; doi:10.3390/ijerph120809054

Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model

1
Molecular Epidemiology Branch, National Cancer Center, Goyang 410-769, Korea
2
Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 330-714, Korea
3
Department of Food and Nutrition, College of Human Ecology, Kyung Hee University, Seoul 130-701, Korea
4
Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul 156-756, Korea
5
Department of Preventive Medicine and Heavy Metal Exposure Environmental Health Center, Dong-A University, Busan 602-714, Korea
6
Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 130-722, Korea
7
Advanced Analysis Center, Korea Institute of Science and Technology, Seoul 130-722, Korea
8
Department of Epidemiology and Biostatistics, School of Public health, Seoul National University, Seoul 151-742, Korea
9
Department of Preventive Medicine, College of Medicine, Chonnam National University, Gwangju 501-746, Korea
10
Department of Preventive Medicine, School of Medicine, Kangwon National University, Chuncheon 200-701, Korea
11
Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 362-763, Korea
12
Department of Environmental Health, Korea National Open University, Seoul 110-791, Korea
13
Institute of Environmental Safety and Protection, NeoEnBiz Co., Bucheon 420-130, Korea
14
Food Safety Risk Assessment Division, National Institute of Food and Drug Safety Evaluation, Cheongwon 363-700, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 21 May 2015 / Revised: 15 July 2015 / Accepted: 28 July 2015 / Published: 31 July 2015
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Abstract

Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 ± 8.6 days. The population mean of the methylmercury half-life was 81.6 ± 8.4 days for men and 78.9 ± 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 ± 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values. View Full-Text
Keywords: biological half-life; dietary exposure; methylmercury; one-compartment toxicokinetic model; population model biological half-life; dietary exposure; methylmercury; one-compartment toxicokinetic model; population model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jo, S.; Woo, H.D.; Kwon, H.-J.; Oh, S.-Y.; Park, J.-D.; Hong, Y.-S.; Pyo, H.; Park, K.S.; Ha, M.; Kim, H.; Sohn, S.-J.; Kim, Y.-M.; Lim, J.-A.; Lee, S.-A.; Eom, S.-Y.; Kim, B.-G.; Lee, K.-M.; Lee, J.-H.; Hwang, M.S.; Kim, J. Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model. Int. J. Environ. Res. Public Health 2015, 12, 9054-9067.

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