Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model
AbstractMethylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 ± 8.6 days. The population mean of the methylmercury half-life was 81.6 ± 8.4 days for men and 78.9 ± 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 ± 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values. View Full-Text
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Jo, S.; Woo, H.D.; Kwon, H.-J.; Oh, S.-Y.; Park, J.-D.; Hong, Y.-S.; Pyo, H.; Park, K.S.; Ha, M.; Kim, H.; Sohn, S.-J.; Kim, Y.-M.; Lim, J.-A.; Lee, S.-A.; Eom, S.-Y.; Kim, B.-G.; Lee, K.-M.; Lee, J.-H.; Hwang, M.S.; Kim, J. Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model. Int. J. Environ. Res. Public Health 2015, 12, 9054-9067.
Jo S, Woo HD, Kwon H-J, Oh S-Y, Park J-D, Hong Y-S, Pyo H, Park KS, Ha M, Kim H, Sohn S-J, Kim Y-M, Lim J-A, Lee S-A, Eom S-Y, Kim B-G, Lee K-M, Lee J-H, Hwang MS, Kim J. Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model. International Journal of Environmental Research and Public Health. 2015; 12(8):9054-9067.Chicago/Turabian Style
Jo, Seongil; Woo, Hae D.; Kwon, Ho-Jang; Oh, Se-Young; Park, Jung-Duck; Hong, Young-Seoub; Pyo, Heesoo; Park, Kyung S.; Ha, Mina; Kim, Ho; Sohn, Seok-Joon; Kim, Yu-Mi; Lim, Ji-Ae; Lee, Sang-Ah; Eom, Sang-Yong; Kim, Byoung-Gwon; Lee, Kyoung-Mu; Lee, Jong-Hyeon; Hwang, Myung S.; Kim, Jeongseon. 2015. "Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model." Int. J. Environ. Res. Public Health 12, no. 8: 9054-9067.