Next Article in Journal
Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults
Previous Article in Journal
Application of Multi-Species Microbial Bioassay to Assess the Effects of Engineered Nanoparticles in the Aquatic Environment: Potential of a Luminous Microbial Array for Toxicity Risk Assessment (LumiMARA) on Testing for Surface-Coated Silver Nanoparticles
Article Menu

Export Article

Open AccessReview
Int. J. Environ. Res. Public Health 2015, 12(7), 8187-8197; doi:10.3390/ijerph120708187

PM2.5 and Cardiovascular Diseases in the Elderly: An Overview

1
Department of Clinical Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China
2
Department of Cardiology, The First People's Hospital of Kunshan Affiliated to Jiangsu University, 91 Qianjin West Road, Kunshan 215132, China
3
Department of Preventive Medicine and Public Health Laboratory Sciences, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China
4
Center of Experimental Research, The First People's Hospital of Kunshan Affiliated to Jiangsu University, 91 Qianjin West Road, Kunshan 215132, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 4 May 2015 / Revised: 19 June 2015 / Accepted: 25 June 2015 / Published: 16 July 2015
View Full-Text   |   Download PDF [746 KB, uploaded 16 July 2015]   |  

Abstract

Background: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in the elderly and the ambient concentration of PM2.5 has been associated with several cardiovascular diseases. Methods: We describe the present state of planetary air pollution, analyze epidemiological studies linking PM2.5 and CVD, and discuss multiple pathophysiological mechanisms linking PM2.5 and CVD. Results: A few epidemiological studies show that the elderly appear specifically susceptible to adverse cardiovascular effects triggered by PM2.5 exposure. Plausible pathophysiological mechanisms include inflammatory dysfunction, oxidative stress, abnormal activation of the hemostatic system and disturbance of the autonomic nervous system. Conclusions: An in-depth knowledge of the chemical compounds, pathophysiological mechanisms, and epidemiological studies of PM2.5 are recommended to understand this important and modifiable factor contributing to geriatric CVD burden. We offer public health recommendations to reduce this preventable cause of disease and death. View Full-Text
Keywords: PM2.5; Cardiovascular disease (CVD); the elderly; susceptibility PM2.5; Cardiovascular disease (CVD); the elderly; susceptibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wang, C.; Tu, Y.; Yu, Z.; Lu, R. PM2.5 and Cardiovascular Diseases in the Elderly: An Overview. Int. J. Environ. Res. Public Health 2015, 12, 8187-8197.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top