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Int. J. Environ. Res. Public Health 2015, 12(7), 7647-7655; doi:10.3390/ijerph120707647

The Prevalence of Dry Eye Syndrome’s and the Likelihood to Develop Sjögren’s Syndrome in Taiwan: A Population-Based Study

1
Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110 Taiwan
2
Department of Ophthalmology, Taipei City Hospital, Zhongxiao Branch, Taipei 115, Taiwan
3
School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
4
Ministry of Health and Welfare, Taipei 115, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 29 March 2015 / Revised: 17 June 2015 / Accepted: 25 June 2015 / Published: 8 July 2015
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Abstract

Background: Dry eye syndrome (DES) is one of the key clinical features and possibly an early clinical presentation of Sjögren’s syndrome (SS). We explore DES prevalence and assess the likelihood of DES patients to develop SS in Taiwan through the National Health Insurance Research Database (NHIRD). Methods: Through a cohort comparison study, longitudinal data from the NHIRD (2000 to 2008) in Taiwan was used to probe the prevalence of DES and the odds that DES patients would later develop SS. Results: The prevalence of DES in the present study is 4.87%. The incidence rates of developing SS were 4.8% for the DES group and 1.5% for comparison group. The median age and interquartile range of DES and comparison patients was 49.8 (10) and 48.7 (15) years old, respectively. The crude hazard ratio (with 95% confidence interval) for DES patients to develop SS was 3.13 (3.10–3.50) for the DES group, and the adjusted hazard ratio (with 95% confidence interval) was 3.64 (3.43–3.87). The observation period and interquartile range for DES and comparison patients to develop SS later were 1418 (781–2316) versus 1641 (971–2512) days respectively. Conclusions: DES patients carried a higher risk for developing SS (hazard ratio 3.13) and presented for SS 3.88 years earlier than comparison group patients in this study. View Full-Text
Keywords: prevalence; dry eye syndrome (DES); Sjögren’s syndrome (SS); National Health Insurance Research Database (NHIRD) prevalence; dry eye syndrome (DES); Sjögren’s syndrome (SS); National Health Insurance Research Database (NHIRD)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yen, J.-C.; Hsu, C.-A.; Li, Y.-C.J.; Hsu, M.-H. The Prevalence of Dry Eye Syndrome’s and the Likelihood to Develop Sjögren’s Syndrome in Taiwan: A Population-Based Study. Int. J. Environ. Res. Public Health 2015, 12, 7647-7655.

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