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Int. J. Environ. Res. Public Health 2015, 12(11), 14275-14284;

Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease

Department of Medical Ultrasonics, Ma’anshan People’s Hospital, Ma’anshan 243000, China
School of Public Health, Wannan Medical College, Wuhu 241000, China
Center of Clinical Laboratory, Ma’anshan Medical Group, Ma’anshan 243000, China
School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China
School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 21 September 2015 / Revised: 15 October 2015 / Accepted: 23 October 2015 / Published: 9 November 2015
Full-Text   |   PDF [708 KB, uploaded 9 November 2015]   |  


Background: The carotid artery plaque score (PS) is an independent predictor of Coronary Heart Disease (CHD). This study aims to evaluate the combination of PS and carotid hemodynamics to predict CHD. Methods: A total of 476 patients who underwent carotid ultrasonography and coronary angiography were divided into two groups depending on the presence of CHD. PS, carotid intima-media thickness, and carotid blood flow were measured. Receiver operating characteristic curve analysis was performed to establish the best prediction model for CHD presence. Results: Age, sex, carotid intima-media thickness of internal carotid artery and carotid bifurcation, PS, peak systolic velocity (PSA) of right internal carotid artery (RICA), and most resistance index data were significantly related with the presence of CHD. The area under the curve for a collective model, which included factors of the PS, carotid hemodynamics and age, was significantly higher than the other model. Age, PS, and PSA of RICA were significant contributors for predicting CHD presence. Conclusions: The model of PS and PSA of RICA has greater predictive value for CHD than PS alone. Adding age to PS and PSA of RICA further improves predictive value over PS alone. View Full-Text
Keywords: carotid intima-media thickness; carotid ultrasonography; coronary angiograph carotid intima-media thickness; carotid ultrasonography; coronary angiograph

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Zhang, H.; Liu, M.; Ren, T.; Wang, X.; Liu, D.; Xu, M.; Han, L.; Wu, Z.; Li, H.; Zhu, Y.; Wen, Y.; Sun, W. Associations between Carotid Artery Plaque Score, Carotid Hemodynamics and Coronary Heart Disease. Int. J. Environ. Res. Public Health 2015, 12, 14275-14284.

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