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Int. J. Environ. Res. Public Health 2015, 12(11), 13913-13922; doi:10.3390/ijerph121113913

Association between Vitamin D Receptor Gene Polymorphisms with Childhood Temporal Lobe Epilepsy

1
Institute of Clinical Pharmacy and Pharmacology, Second Xiangya Hospital, Central South University, Changsha 410011, China
2
Department of Pharmacy, Jining First People’s Hospital, Jining 272011, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 27 August 2015 / Revised: 27 October 2015 / Accepted: 28 October 2015 / Published: 30 October 2015
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Abstract

Vitamin D (VD) is implicated in multiple aspects of human physiology and vitamin D receptor (VDR) polymorphisms are associated with a variety of neuropsychiatric disorders. Although VD deficiency is highly prevalent in epilepsy patients and converging evidence indicates a role for VD in the development of epilepsy, no data is available on the possible relationship between epilepsy and genetic variations of VDR. In this study, 150 controls and 82 patients with temporal lobe epilepsy (TLE) were genotyped for five common VDR polymorphisms (Cdx-2, FokI, BsmI, ApaI and TaqI) by the polymerase chain reaction-ligase detection reaction method. Our results revealed that the frequency of FokI AC genotype was significantly higher in the control group than in the patients (p = 0.003, OR = 0.39, 95% CI = 0.21–0.73), whereas the AA genotype of ApaI SNP was more frequent in patients than in controls (p = 0.018, OR = 2.92, 95% CI = 1.2–7.1). However, no statistically significant association was found between Cdx-2, BsmI and TaqI polymorphisms and epilepsy. Additionally, in haplotype analysis, we found the haplotype GAT (BsmI/ApaI/TaqI) conferred significantly increased risk for developing TLE (p = 0.039, OR = 1.62, 95% CI = 1.02–2.56). As far as we know, these results firstly underline the importance of VDR polymorphisms for the genetic susceptibility to epilepsy. View Full-Text
Keywords: epilepsy; children; vitamin D receptor; polymorphisms epilepsy; children; vitamin D receptor; polymorphisms
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jiang, P.; Zhu, W.-Y.; He, X.; Tang, M.-M.; Dang, R.-L.; Li, H.-D.; Xue, Y.; Zhang, L.-H.; Wu, Y.-Q.; Cao, L.-J. Association between Vitamin D Receptor Gene Polymorphisms with Childhood Temporal Lobe Epilepsy. Int. J. Environ. Res. Public Health 2015, 12, 13913-13922.

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