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Addendum published on 8 November 2016, see Int. J. Environ. Res. Public Health 2016, 13(11), 1108.

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Int. J. Environ. Res. Public Health 2014, 11(9), 9897-9918; doi:10.3390/ijerph110909897

Mitochondrial Toxicity in Human Pregnancy: An Update on Clinical and Experimental Approaches in the Last 10 Years

1
Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS-Faculty of Medicine-University of Barcelona, Internal Medicine Service-Hospital Clínic of Barcelona, Barcelona 08036, Spain
2
Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Raras, CIBERER, Valencia 46010, Spain
3
Materno-Fetal Medicine Department, Clinical Institute of Gynaecology, Obstetrics and Neonatology, Barcelona 08025, Spain
*
Author to whom correspondence should be addressed.
Received: 31 July 2014 / Revised: 5 September 2014 / Accepted: 17 September 2014 / Published: 22 September 2014
(This article belongs to the Special Issue Maternal and Child Health)
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Abstract

Mitochondrial toxicity can be one of the most dreadful consequences of exposure to a wide range of external agents including pathogens, therapeutic agents, abuse drugs, toxic gases and other harmful chemical substances. However, little is known about the effects of mitochondrial toxicity on pregnant women exposed to these agents that may exert transplacental activity and condition fetal remodeling. It has been hypothesized that mitochondrial toxicity may be involved in some adverse obstetric outcomes. In the present study, we investigated the association between exposure to mitochondrial toxic agents and pathologic conditions ranging from fertility defects, detrimental fetal development and impaired newborn health due to intra-uterine exposure. We have reviewed data from studies in human subjects to propose mechanisms of mitochondrial toxicity that could be associated with the symptoms present in both exposed pregnant and fetal patients. Since some therapeutic interventions or accidental exposure cannot be avoided, further research is needed to gain insight into the molecular pathways leading to mitochondrial toxicity during pregnancy. The ultimate objective of these studies should be to reduce the mitochondrial toxicity of these agents and establish biomarkers for gestational monitoring of harmful effects. View Full-Text
Keywords: Mitochondria; toxic effects; pregnancy; adverse obstetric outcome Mitochondria; toxic effects; pregnancy; adverse obstetric outcome
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Morén, C.; Hernández, S.; Guitart-Mampel, M.; Garrabou, G. Mitochondrial Toxicity in Human Pregnancy: An Update on Clinical and Experimental Approaches in the Last 10 Years. Int. J. Environ. Res. Public Health 2014, 11, 9897-9918.

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