Next Article in Journal
Correction: Stauber, C.E., et al. Evaluation of the Impact of the Plastic BioSand Filter on Health and Drinking Water Quality in Rural Tamale, Ghana. Int. J. Environ. Res. Public Health 2012, 9, 3806–3823
Previous Article in Journal
Fast Inverse Distance Weighting-Based Spatiotemporal Interpolation: A Web-Based Application of Interpolating Daily Fine Particulate Matter PM2.5 in the Contiguous U.S. Using Parallel Programming and k-d Tree
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2014, 11(9), 9142-9153; doi:10.3390/ijerph110909142

The Effects of Non-Invasive Radiofrequency Treatment and Hyperthermia on Malignant and Nonmalignant Cells

1
Department of Surgical Oncology, Baylor College of Medicine, Houston, TX 77030, USA
2
Department of Mechanical Engineering and Materials Science, Rice University, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Received: 1 August 2014 / Revised: 18 August 2014 / Accepted: 25 August 2014 / Published: 3 September 2014
View Full-Text   |   Download PDF [393 KB, uploaded 3 September 2014]   |  

Abstract

Background: Exposure of biological subjects to electromagnetic fields with a high frequency is associated with temperature elevation. In our recent studies, we reported that non-invasive radiofrequency (RF) treatment at 13.56 MHz with the field ranging from 1 KeV to 20 KeV/m2 inhibits tumor progression in animals with abdominal tumor xenografts and enhances the anticancer effect of chemotherapy. The RF treatment was followed by temperature elevation in tumors to approximately 46 °C during 10 min of exposure. In contrast, the temperature of normal tissues remained within a normal range at approximately 37 °C. Whether all biological effects of RF treatment are limited to its hyperthermic property remains unclear. Here, we compared how RF and hyperthermia (HT) treatments change the proliferation rate, oxygen consumption and autophagy in malignant and nonmalignant cells. Methods: In the current study, cancer and nonmalignant cells of pancreatic origin were exposed to the RF field or to conventional HT at 46 °C, which was chosen based on our previous in vivo studies of the tumor-specific RF-induced hyperthermia. Results: Only RF treatment caused declines in cancer cell viability and proliferation. RF treatment also affected mitochondrial function in cancer cells more than HT treatment did and, unlike HT treatment, was followed by the elevation of autophagosomes in the cytoplasm of cancer cells. Importantly, the effects of RF treatment were negligible in nonmalignant cells. Conclusion: The obtained data indicate that the effects of RF treatment are specific to cancer cells and are not limited to its hyperthermic property. View Full-Text
Keywords: electromagnetic waves; hyperthermia; cancer; autophagy; mitochondria; proliferation electromagnetic waves; hyperthermia; cancer; autophagy; mitochondria; proliferation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Curley, S.A.; Palalon, F.; Sanders, K.E.; Koshkina, N.V. The Effects of Non-Invasive Radiofrequency Treatment and Hyperthermia on Malignant and Nonmalignant Cells. Int. J. Environ. Res. Public Health 2014, 11, 9142-9153.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top