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Int. J. Environ. Res. Public Health 2014, 11(8), 7918-7930; doi:10.3390/ijerph110807918

Effects of Nano-MnO2 on Dopaminergic Neurons and the Spatial Learning Capability of Rats

1,2,†
,
2,†
,
1
,
2
,
1
and
1,*
1
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
2
Institute of Neurobiology, Southeast University, Nanjing 210009, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 24 June 2014 / Revised: 16 July 2014 / Accepted: 25 July 2014 / Published: 6 August 2014
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Abstract

This study aimed to observe the effect of intracerebrally injected nano-MnO2 on neurobehavior and the functions of dopaminergic neurons and astrocytes. Nano-MnO2, 6-OHDA, and saline (control) were injected in the substantia nigra and the ventral tegmental area of Sprague-Dawley rat brains. The neurobehavior of rats was evaluated by Morris water maze test. Tyrosine hydroxylase (TH), inducible nitric oxide synthase (iNOS) and glial fibrillary acidic protein (GFAP) expressions in rat brain were detected by immunohistochemistry. Results showed that the escape latencies of nano-MnO2 treated rat increased significantly compared with control. The number of TH-positive cells decreased, GFAP- and iNOS-positive cells increased significantly in the lesion side of the rat brains compared with the contralateral area in nano-MnO2 group. The same tendencies were observed in nano-MnO2-injected rat brains compared with control. However, in the the positive control, 6-OHDA group, escape latencies increased, TH-positive cell number decreased significantly compared with nano-MnO2 group. The alteration of spatial learning abilities of rats induced by nano-MnO2 may be associated with dopaminergic neuronal dysfunction and astrocyte activation. View Full-Text
Keywords: nano-MnO2; Morris water maze; dopaminergic neurons; glial fibrillary acidic protein nano-MnO2; Morris water maze; dopaminergic neurons; glial fibrillary acidic protein
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MDPI and ACS Style

Li, T.; Shi, T.; Li, X.; Zeng, S.; Yin, L.; Pu, Y. Effects of Nano-MnO2 on Dopaminergic Neurons and the Spatial Learning Capability of Rats. Int. J. Environ. Res. Public Health 2014, 11, 7918-7930.

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