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Int. J. Environ. Res. Public Health 2014, 11(8), 7841-7855; doi:10.3390/ijerph110807841

Effects of Simulated Heat Waves on Cardiovascular Functions in Senile Mice

1
School of Atmospheric Science, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China
2
Computer Science Department, Oklahoma State University, 219 MSCS, Stillwater, OK 74078, USA
3
Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province, Lanzhou Institute of Arid Meteorology, China Meteorological Administration, 2070 Donggang East Road, Lanzhou 730020, China
4
School of Applied Meteorology, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China
5
Lanzhou Central Meteorological Observatory, 2070 Donggang East Road, Lanzhou 730020, China
*
Author to whom correspondence should be addressed.
Received: 12 May 2014 / Revised: 26 July 2014 / Accepted: 29 July 2014 / Published: 6 August 2014
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Abstract

The mechanism of the effects of simulated heat waves on cardiovascular disease in senile mice was investigated. Heat waves were simulated in a TEM1880 meteorological environment simulation chamber, according to a heat wave that occurred in July 2001 in Nanjing, China. Eighteen senile mice were divided into control, heat wave, and heat wave BH4 groups, respectively. Mice in the heat wave and heat wave BH4 groups were exposed to simulated heat waves in the simulation chamber. The levels of ET-1, NO, HSP60, SOD, TNF, sICAM-1, and HIF-1α in each group of mice were measured after heat wave simulation. Results show that heat waves decreased SOD activity in the myocardial tissue of senile mice, increased NO, HSP60, TNF, sICAM-1, and HIF-1α levels, and slightly decreased ET-1 levels, BH4 can relieve the effects of heat waves on various biological indicators. After a comprehensive analysis of the experiments above, we draw the followings conclusions regarding the influence of heat waves on senile mice: excess HSP60 activated immune cells, and induced endothelial cells and macrophages to secrete large amounts of ICAM-1, TNF-α, and other inflammatory cytokines, it also activated the inflammation response in the body and damaged the coronary endothelial cell structure, which increased the permeability of blood vessel intima and decreased SOD activity in cardiac tissues. The oxidation of lipoproteins in the blood increased, and large amounts of cholesterol were generated. Cholesterol penetrated the intima and deposited on the blood vessel wall, forming atherosclerosis and leading to the occurrence of cardiovascular disease in senile mice. These results maybe are useful for studying the effects of heat waves on elderly humans, which we discussed in the discussion chapter. View Full-Text
Keywords: heat wave weather; senile mice; HSP60; SOD; TNF; sICAM-1; atherosclerosis heat wave weather; senile mice; HSP60; SOD; TNF; sICAM-1; atherosclerosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, X.; Lu, J.; Zhang, S.; Wang, C.; Wang, B.; Guo, P.; Dong, L. Effects of Simulated Heat Waves on Cardiovascular Functions in Senile Mice. Int. J. Environ. Res. Public Health 2014, 11, 7841-7855.

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Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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