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Int. J. Environ. Res. Public Health 2014, 11(8), 7636-7641; doi:10.3390/ijerph110807636
Article

Associations Between Subjective Symptoms and Serum Immunoglobulin E Levels During Asian Dust Events

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Received: 8 April 2014 / Revised: 15 July 2014 / Accepted: 16 July 2014 / Published: 29 July 2014
(This article belongs to the Special Issue Genetic Impact on the Development of Allergic Disease)
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Abstract

Asian dust is a seasonal meteorological phenomenon caused by the displacement of atmospheric pollutants from the Mongolian and Chinese deserts. Although the frequency of Asian dust events and atmospheric dust levels have steadily increased in the eastern Asia region, the effects on human health remain poorly understood. In the present study, the impact of Asian dust on human health was determined in terms of allergic reactions. A total of 25 healthy volunteers were tested for a relationship between serum immunoglobulin E (IgE) levels and subjective symptoms during a 3-day Asian dust event recorded in April 2012. They filled daily questionnaires on the severity of nasal, pharyngeal, ocular, respiratory, and skin symptoms by a self-administered visual analog scale. Serum levels of non-specific IgE and 33 allergen-specific IgE molecules were analyzed. Spearman rank-correlation analysis revealed significant positive associations between nasal symptom scores and 2 microbial-specific IgE levels (Penicillium and Cladosporium). Microbes migrate vast distances during Asian dust events by attaching themselves to dust particles. Therefore, some of these symptoms may be associated with type 1 allergic reactions to certain type of microbes.
Keywords: Asian dust; type 1 allergic reaction; immunoglobulin E Asian dust; type 1 allergic reaction; immunoglobulin E
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Otani, S.; Onishi, K.; Mu, H.; Hosoda, T.; Kurozawa, Y.; Ikeguchi, M. Associations Between Subjective Symptoms and Serum Immunoglobulin E Levels During Asian Dust Events. Int. J. Environ. Res. Public Health 2014, 11, 7636-7641.

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