Serum Lipid Profiles, Lipid Ratios and Chronic Kidney Disease in a Chinese Population
AbstractAim: To examine the association of serum lipids, lipid ratios with Chronic Kidney Disease (CKD) in a Chinese population. Methods: Data were drawn from a cross-sectional survey in China. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 or albuminuria-to-creatinine ratio (ACR) > 30 mg/g. Multivariable logistic regressions and multivariate regression models were used. Serum lipids and lipid ratios included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio. Results: In men, only logarithm-transformed (log) TG was associated with CKD. The odds ratio (every SD increment) was 1.39 (95% CI 1.03–1.87, P = 0.03). In women, none of the serum lipids and lipid ratios was associated with CKD. Using multivariate regression models, it was shown that log TG and log TG/HDL-C were negatively correlated with eGFR (P < 0.05) in men and LDL-C and log LDL-C/HDL-C ratio were correlated with ACR in men. In female subjects, serum TC, log TG, log TG/HDL-C and log TC/HDL-C were negatively correlated with eGFR (P < 0.05). All of serum lipid profiles and lipid related ratio were not correlated with ACR in women. Conclusion: Serum TG is the only suitable predictor for CKD in men. However, in women, none of serum lipids and lipid ratio can be used as a predictor for CKD. Log TG and log TG/HDL-C are negatively correlated with eGFR in both genders. View Full-Text
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Zhang, L.; Yuan, Z.; Chen, W.; Chen, S.; Liu, X.; Liang, Y.; Shao, X.; Zou, H. Serum Lipid Profiles, Lipid Ratios and Chronic Kidney Disease in a Chinese Population. Int. J. Environ. Res. Public Health 2014, 11, 7622-7635.
Zhang L, Yuan Z, Chen W, Chen S, Liu X, Liang Y, Shao X, Zou H. Serum Lipid Profiles, Lipid Ratios and Chronic Kidney Disease in a Chinese Population. International Journal of Environmental Research and Public Health. 2014; 11(8):7622-7635.Chicago/Turabian Style
Zhang, Liying; Yuan, Zhiyong; Chen, Wu; Chen, Shanying; Liu, Xinyu; Liang, Yan; Shao, Xiaofei; Zou, Hequn. 2014. "Serum Lipid Profiles, Lipid Ratios and Chronic Kidney Disease in a Chinese Population." Int. J. Environ. Res. Public Health 11, no. 8: 7622-7635.