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Int. J. Environ. Res. Public Health 2014, 11(4), 4544-4554; doi:10.3390/ijerph110404544
Article

Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth

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Received: 19 December 2013; in revised form: 8 April 2014 / Accepted: 14 April 2014 / Published: 23 April 2014
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Abstract: To investigate the effects of a high-carbohydrate and low-fat (HC/LF) diet on plasma lipids and apolipoproteins (Apos) of healthy Chinese Han youth with different genotypes of lipoprotein lipase gene (LPL) rs326, 56 subjects were given a washout diet of 30.1% fat and 54.1% carbohydrate for seven days, followed by the HC/LF diet of 13.8% fat and 70.1% carbohydrate for six days, with no total energy restriction. Plasma glucose, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), Apo B-100 and Apo A-I were analyzed at baseline and before and after the HC/LF diet. The results show that, when compared with before the HC/LF diet, only the male G carriers experienced increased HDL-C (p = 0.008) and Apo A-I (p = 0.005) after the HC/LF diet. Decreased TC in both males and females and increased TG in females were found regardless of the genotype after the HC/LF diet. LDL-C decreased in all the subjects although the decrease was not significant in the female G carriers. These results demonstrate that the G allele of LPL rs326 associates with the elevated levels of HDL-C and Apo A-I after the HC/LF diet in males of the healthy Chinese Han Youth.
Keywords: apolipoproteins; HC/LF diet; high density lipoprotein cholesterol; single nucleotide polymorphism; lipoprotein lipase apolipoproteins; HC/LF diet; high density lipoprotein cholesterol; single nucleotide polymorphism; lipoprotein lipase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhu, X.-C.; Lin, J.; Wang, Q.; Liu, H.; Qiu, L.; Fang, D.-Z. Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth. Int. J. Environ. Res. Public Health 2014, 11, 4544-4554.

AMA Style

Zhu X-C, Lin J, Wang Q, Liu H, Qiu L, Fang D-Z. Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth. International Journal of Environmental Research and Public Health. 2014; 11(4):4544-4554.

Chicago/Turabian Style

Zhu, Xing-chun; Lin, Jia; Wang, Qian; Liu, Hui; Qiu, Li; Fang, Ding-zhi. 2014. "Associations of Lipoprotein Lipase Gene rs326 with Changes of Lipid Profiles after a High-Carbohydrate and Low-Fat Diet in Healthy Chinese Han Youth." Int. J. Environ. Res. Public Health 11, no. 4: 4544-4554.


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