Int. J. Environ. Res. Public Health 2013, 10(6), 2271-2281; doi:10.3390/ijerph10062271
Article

Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure

Received: 12 April 2013; in revised form: 24 May 2013 / Accepted: 27 May 2013 / Published: 4 June 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Concentrations of pesticides and selected metabolites in rat urine and amniotic fluid were determined as biomarker upon oral administration of Wistar rats to two pesticide mixtures consisting of three to five pesticides (bitertanol, propiconazole, cypermethrin, malathion, and terbuthylazine). The pesticides and their metabolites were found in rat amniotic fluid and urine, generally in dose-response concentrations in relation to dosage. The measurement of the substances in the amniotic fluid indicated that the fetus was exposed to the pesticides as well as their metabolites. Moreover, the pesticides detected in urine demonstrated the exposure as well as the ability of the rat to excrete these compounds.
Keywords: pesticides; gestational exposure; in vivo experiment; Wistar rats
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MDPI and ACS Style

Bossi, R.; Vinggaard, A.M.; Taxvig, C.; Boberg, J.; Bonefeld-Jørgensen, E.C. Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure. Int. J. Environ. Res. Public Health 2013, 10, 2271-2281.

AMA Style

Bossi R, Vinggaard AM, Taxvig C, Boberg J, Bonefeld-Jørgensen EC. Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure. International Journal of Environmental Research and Public Health. 2013; 10(6):2271-2281.

Chicago/Turabian Style

Bossi, Rossana; Vinggaard, Anne M.; Taxvig, Camilla; Boberg, Julie; Bonefeld-Jørgensen, Eva C. 2013. "Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure." Int. J. Environ. Res. Public Health 10, no. 6: 2271-2281.

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