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Investigation into the Nephrotoxicity of Nigerian Bonny Light Crude Oil in Albino Rats
Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.M.B 5001, Nnewi, Anambra State, Nigeria
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu, Abuja, Nigeria
Department of Anatomy, College of Health Sciences, Abia State University, Uturu, Nigeria
* Author to whom correspondence should be addressed.
Received: 21 December 2003; Accepted: 18 May 2004 / Published: 30 September 2004
Abstract: The effect of bonny-light crude oil was assessed in adult albino rats. The rats were administered with 200, 400, and 800mg/kg body weight of the crude oil orally for 7 days. Fluid intake was measured daily, initial and final animal body was recorded. The toxic effects on the kidneys were assessed and histological studies carried out. The results revealed that the kidney cells were damaged; crude oil caused a destruction of the renal reserve capacity. There was a significant increase (p ≤ 0.05) in creatinine in the high dose group (800mg/kg), and a significant decrease (p ≤ 0.05) in urea concentration. Histological examination indicates that crude oil induced severe pathologic changes in the forms of necrosis and oedema.
Keywords: bonny light; crude oil; nephrotoxicity
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Orisakwe, O.E.; Njan, A.A.; Afonne, O.J.; D, A.D.; Orish, V.N.; Udemezue, O.O. Investigation into the Nephrotoxicity of Nigerian Bonny Light Crude Oil in Albino Rats. Int. J. Environ. Res. Public Health 2004, 1, 106-110.
Orisakwe OE, Njan AA, Afonne OJ, D AD, Orish VN, Udemezue OO. Investigation into the Nephrotoxicity of Nigerian Bonny Light Crude Oil in Albino Rats. International Journal of Environmental Research and Public Health. 2004; 1(2):106-110.
Orisakwe, O. E.; Njan, A. A.; Afonne, O. J.; D, Akumka D.; Orish, V. N.; Udemezue, O. O. 2004. "Investigation into the Nephrotoxicity of Nigerian Bonny Light Crude Oil in Albino Rats." Int. J. Environ. Res. Public Health 1, no. 2: 106-110.