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Int. J. Environ. Res. Public Health 2004, 1(2), 106-110; doi:10.3390/ijerph2004020106
Article

Investigation into the Nephrotoxicity of Nigerian Bonny Light Crude Oil in Albino Rats

1,* , 2, 1, 1, 1 and 3
Received: 21 December 2003; Accepted: 18 May 2004 / Published: 30 September 2004
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Abstract: The effect of bonny-light crude oil was assessed in adult albino rats. The rats were administered with 200, 400, and 800mg/kg body weight of the crude oil orally for 7 days. Fluid intake was measured daily, initial and final animal body was recorded. The toxic effects on the kidneys were assessed and histological studies carried out. The results revealed that the kidney cells were damaged; crude oil caused a destruction of the renal reserve capacity. There was a significant increase (p ≤ 0.05) in creatinine in the high dose group (800mg/kg), and a significant decrease (p ≤ 0.05) in urea concentration. Histological examination indicates that crude oil induced severe pathologic changes in the forms of necrosis and oedema.
Keywords: bonny light; crude oil; nephrotoxicity bonny light; crude oil; nephrotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Orisakwe, O.E.; Njan, A.A.; Afonne, O.J.; D, A.D.; Orish, V.N.; Udemezue, O.O. Investigation into the Nephrotoxicity of Nigerian Bonny Light Crude Oil in Albino Rats. Int. J. Environ. Res. Public Health 2004, 1, 106-110.

AMA Style

Orisakwe OE, Njan AA, Afonne OJ, D AD, Orish VN, Udemezue OO. Investigation into the Nephrotoxicity of Nigerian Bonny Light Crude Oil in Albino Rats. International Journal of Environmental Research and Public Health. 2004; 1(2):106-110.

Chicago/Turabian Style

Orisakwe, O. E.; Njan, A. A.; Afonne, O. J.; D, Akumka D.; Orish, V. N.; Udemezue, O. O. 2004. "Investigation into the Nephrotoxicity of Nigerian Bonny Light Crude Oil in Albino Rats." Int. J. Environ. Res. Public Health 1, no. 2: 106-110.


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