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Aqueous and Methanolic Extracts of Caulerpa mexicana Suppress Cell Migration and Ear Edema Induced by Inflammatory Agents
Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, University Campus, Lagoa Nova, 59078-900, Natal, RN, Brazil
Laboratory of Technology Pharmaceutical, Federal University of Paraiba, 58051-900, Joao Pessoa, PB, Brazil
Laboratory of Marine Algae, Department of Systematics and Ecology, Federal University of Paraiba, 58051-900, Joao Pessoa, PB, Brazil
* Authors to whom correspondence should be addressed.
Received: 30 June 2011; in revised form: 18 July 2011 / Accepted: 4 August 2011 / Published: 10 August 2011
Abstract: The regulation of the inflammatory response is essential to maintaining homeostasis. Several studies have investigated new drugs that may contribute to avoiding or minimizing excessive inflammatory process. The aim of this study was to evaluate the effect of extracts of green algae Caulerpa mexicana on models inflammation. In mice, the inflammatory peritonitis model is induced by zymosan. Previous treatment of mice with aqueous and methanolic extracts of C. mexicana was able to suppress the cell migration to the peritoneal cavity, in a time-dependent but not in a dose-dependent manner. The treatment of mice with C. mexicana extracts also decreased the xylene-induced ear edema, exerting strong inhibitory leukocyte migration elicited by zymosan into the air pouch. We concluded that administration of the extracts resulted in a reduction of cell migration to different sites as well as a decrease in edema formation induced by chemical irritants. This study demonstrates for the first time the anti-inflammatory effect of aqueous and methanolic extracts from the green marine algae Caulerpa mexicana.
Keywords: Caulerpa mexicana; green algae; zymosan; inflammation; edema; cell migration
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Bitencourt, M.A.O.; Dantas, G.R.; Lira, D.P.; Barbosa-Filho, J.M.; Miranda, G.E.C.; Santos, B.V.O.; Souto, J.T. Aqueous and Methanolic Extracts of Caulerpa mexicana Suppress Cell Migration and Ear Edema Induced by Inflammatory Agents. Mar. Drugs 2011, 9, 1332-1345.
Bitencourt MAO, Dantas GR, Lira DP, Barbosa-Filho JM, Miranda GEC, Santos BVO, Souto JT. Aqueous and Methanolic Extracts of Caulerpa mexicana Suppress Cell Migration and Ear Edema Induced by Inflammatory Agents. Marine Drugs. 2011; 9(8):1332-1345.
Bitencourt, Mariana Angelica Oliveira; Dantas, Gracielle Rodrigues; Lira, Daysianne Pereira; Barbosa-Filho, Jose Maria; Miranda, George Emmanuel Cavalcanti de; Santos, Barbara Viviana de Oliveira; Souto, Janeusa Trindade. 2011. "Aqueous and Methanolic Extracts of Caulerpa mexicana Suppress Cell Migration and Ear Edema Induced by Inflammatory Agents." Mar. Drugs 9, no. 8: 1332-1345.