Mar. Drugs 2011, 9(8), 1319-1331; doi:10.3390/md9081319
Article

Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum

Received: 5 July 2011; in revised form: 17 July 2011 / Accepted: 28 July 2011 / Published: 5 August 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Five new cembrane-type diterpenoids, lobocrassins A–E (15), were isolated from the soft coral Lobophytum crassum. The structures of cembranes 15 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Keywords: lobocrassin; cembrane; Lobophytum crassum; cytotoxicity; superoxide anion; elastase
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MDPI and ACS Style

Kao, C.-Y.; Su, J.-H.; Lu, M.-C.; Hwang, T.-L.; Wang, W.-H.; Chen, J.-J.; Sheu, J.-H.; Kuo, Y.-H.; Weng, C.-F.; Fang, L.-S.; Wen, Z.-H.; Sung, P.-J. Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum. Mar. Drugs 2011, 9, 1319-1331.

AMA Style

Kao C-Y, Su J-H, Lu M-C, Hwang T-L, Wang W-H, Chen J-J, Sheu J-H, Kuo Y-H, Weng C-F, Fang L-S, Wen Z-H, Sung P-J. Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum. Marine Drugs. 2011; 9(8):1319-1331.

Chicago/Turabian Style

Kao, Chia-Ying; Su, Jui-Hsin; Lu, Mei-Chin; Hwang, Tsong-Long; Wang, Wei-Hsien; Chen, Jih-Jung; Sheu, Jyh-Horng; Kuo, Yueh-Hsiung; Weng, Ching-Feng; Fang, Lee-Shing; Wen, Zhi-Hong; Sung, Ping-Jyun. 2011. "Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum." Mar. Drugs 9, no. 8: 1319-1331.

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