Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum
AbstractFive new cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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Kao, C.-Y.; Su, J.-H.; Lu, M.-C.; Hwang, T.-L.; Wang, W.-H.; Chen, J.-J.; Sheu, J.-H.; Kuo, Y.-H.; Weng, C.-F.; Fang, L.-S.; Wen, Z.-H.; Sung, P.-J. Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum. Mar. Drugs 2011, 9, 1319-1331.
Kao C-Y, Su J-H, Lu M-C, Hwang T-L, Wang W-H, Chen J-J, Sheu J-H, Kuo Y-H, Weng C-F, Fang L-S, Wen Z-H, Sung P-J. Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum. Marine Drugs. 2011; 9(8):1319-1331.Chicago/Turabian Style
Kao, Chia-Ying; Su, Jui-Hsin; Lu, Mei-Chin; Hwang, Tsong-Long; Wang, Wei-Hsien; Chen, Jih-Jung; Sheu, Jyh-Horng; Kuo, Yueh-Hsiung; Weng, Ching-Feng; Fang, Lee-Shing; Wen, Zhi-Hong; Sung, Ping-Jyun. 2011. "Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum." Mar. Drugs 9, no. 8: 1319-1331.