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Mar. Drugs 2011, 9(6), 944-951; doi:10.3390/md9060944
Article

Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular

1,2,*  and 3
Received: 25 April 2011; in revised form: 19 May 2011 / Accepted: 26 May 2011 / Published: 27 May 2011
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Abstract: Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 15, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 3 and 5 exhibited moderate cytotoxicity to human tumor cell lines CCRF-CEM and DLD-1. Furthermore, 35 displayed significant in vitro anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Metabolites 4 and 5 also effectively reduced the expression of the COX-2 protein in the macrophages.
Keywords: soft coral; Sinularia triangular; cytotoxicity; anti-inflammatory soft coral; Sinularia triangular; cytotoxicity; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Su, J.-H.; Wen, Z.-H. Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular. Mar. Drugs 2011, 9, 944-951.

AMA Style

Su J-H, Wen Z-H. Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular. Marine Drugs. 2011; 9(6):944-951.

Chicago/Turabian Style

Su, Jui-Hsin; Wen, Zhi-Hong. 2011. "Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular." Mar. Drugs 9, no. 6: 944-951.



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