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Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular
National Museum of Marine Biology & Aquarium, Pingtung 944,Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944,Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 25 April 2011; in revised form: 19 May 2011 / Accepted: 26 May 2011 / Published: 27 May 2011
Abstract: Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 1–5, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 3 and 5 exhibited moderate cytotoxicity to human tumor cell lines CCRF-CEM and DLD-1. Furthermore, 3–5 displayed significant in vitro anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Metabolites 4 and 5 also effectively reduced the expression of the COX-2 protein in the macrophages.
Keywords: soft coral; Sinularia triangular; cytotoxicity; anti-inflammatory
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Su, J.-H.; Wen, Z.-H. Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular. Mar. Drugs 2011, 9, 944-951.
Su J-H, Wen Z-H. Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular. Marine Drugs. 2011; 9(6):944-951.
Su, Jui-Hsin; Wen, Zhi-Hong. 2011. "Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular." Mar. Drugs 9, no. 6: 944-951.