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Mar. Drugs 2011, 9(6), 944-951; doi:10.3390/md9060944

Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular

1,2,*  and 3
1 National Museum of Marine Biology & Aquarium, Pingtung 944,Taiwan 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944,Taiwan 3 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Author to whom correspondence should be addressed.
Received: 25 April 2011 / Revised: 19 May 2011 / Accepted: 26 May 2011 / Published: 27 May 2011
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Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 15, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 3 and 5 exhibited moderate cytotoxicity to human tumor cell lines CCRF-CEM and DLD-1. Furthermore, 35 displayed significant in vitro anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Metabolites 4 and 5 also effectively reduced the expression of the COX-2 protein in the macrophages.
Keywords: soft coral; Sinularia triangular; cytotoxicity; anti-inflammatory soft coral; Sinularia triangular; cytotoxicity; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Su, J.-H.; Wen, Z.-H. Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular. Mar. Drugs 2011, 9, 944-951.

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