Next Article in Journal
Antioxidant and Antiproliferative Activities of Heterofucans from the Seaweed Sargassum filipendula
Previous Article in Journal
Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.
Mar. Drugs 2011, 9(6), 944-951; doi:10.3390/md9060944
Article

Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular

1,2,*  and 3
Received: 25 April 2011 / Revised: 19 May 2011 / Accepted: 26 May 2011 / Published: 27 May 2011
View Full-Text   |   Download PDF [362 KB, uploaded 24 February 2015]   |   Browse Figures

Abstract

Chemical examination of the Taiwanese soft coral Sinularia triangular led to the isolation of five cembrane-based diterpenoids 15, including two new metabolites, triangulenes A (1) and B (2). The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 3 and 5 exhibited moderate cytotoxicity to human tumor cell lines CCRF-CEM and DLD-1. Furthermore, 35 displayed significant in vitro anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Metabolites 4 and 5 also effectively reduced the expression of the COX-2 protein in the macrophages.
Keywords: soft coral; Sinularia triangular; cytotoxicity; anti-inflammatory soft coral; Sinularia triangular; cytotoxicity; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplement

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Su, J.-H.; Wen, Z.-H. Bioactive Cembrane-Based Diterpenoids from the Soft Coral Sinularia triangular. Mar. Drugs 2011, 9, 944-951.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert