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Mar. Drugs 2011, 9(6), 934-943; doi:10.3390/md9060934
Article

Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.

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Received: 14 April 2011 / Revised: 18 May 2011 / Accepted: 25 May 2011 / Published: 26 May 2011
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Abstract

Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (–)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.
Keywords: cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, Y.-H.; Tai, C.-Y.; Su, Y.-D.; Chang, Y.-C.; Lu, M.-C.; Weng, C.-F.; Su, J.-H.; Hwang, T.-L.; Wu, Y.-C.; Sung, P.-J. Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.. Mar. Drugs 2011, 9, 934-943.

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