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Mar. Drugs 2011, 9(6), 934-943; doi:10.3390/md9060934
Article

Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.

1
, 1,2
, 1,3
, 1,4
, 1,2
, 5
, 1,2,6
, 7
, 8,9,*  and 1,2,3,5,6,*
1 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 3 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan 5 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 6 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 7 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 8 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan 9 Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 14 April 2011 / Revised: 18 May 2011 / Accepted: 25 May 2011 / Published: 26 May 2011
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Abstract

Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (–)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.
Keywords: cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, Y.-H.; Tai, C.-Y.; Su, Y.-D.; Chang, Y.-C.; Lu, M.-C.; Weng, C.-F.; Su, J.-H.; Hwang, T.-L.; Wu, Y.-C.; Sung, P.-J. Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.. Mar. Drugs 2011, 9, 934-943.

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