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Mar. Drugs 2011, 9(6), 934-943; doi:10.3390/md9060934
Article

Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.

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1 National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 3 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 4 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan 5 Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 6 Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 7 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan 8 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan 9 Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 14 April 2011 / Revised: 18 May 2011 / Accepted: 25 May 2011 / Published: 26 May 2011
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Abstract

Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (–)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.
Keywords: cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Chen, Y.-H.; Tai, C.-Y.; Su, Y.-D.; Chang, Y.-C.; Lu, M.-C.; Weng, C.-F.; Su, J.-H.; Hwang, T.-L.; Wu, Y.-C.; Sung, P.-J. Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.. Mar. Drugs 2011, 9, 934-943.

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