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Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 14 April 2011; in revised form: 18 May 2011 / Accepted: 25 May 2011 / Published: 26 May 2011
Abstract: Two new 11-hydroxyeunicellin diterpenoids, cladieunicellin F (1) and (–)-solenopodin C (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods, and eunicellin 2 was found to be an enantiomer of the known eunicellin solenopodin C (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils. The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study.
Keywords: cladieunicellin; eunicellin; octocoral; Cladiella; superoxide anion; elastase
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Chen, Y.-H.; Tai, C.-Y.; Su, Y.-D.; Chang, Y.-C.; Lu, M.-C.; Weng, C.-F.; Su, J.-H.; Hwang, T.-L.; Wu, Y.-C.; Sung, P.-J. Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.. Mar. Drugs 2011, 9, 934-943.
Chen Y-H, Tai C-Y, Su Y-D, Chang Y-C, Lu M-C, Weng C-F, Su J-H, Hwang T-L, Wu Y-C, Sung P-J. Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.. Marine Drugs. 2011; 9(6):934-943.
Chen, Yung-Husan; Tai, Chia-Ying; Su, Yin-Di; Chang, Yu-Chia; Lu, Mei-Chin; Weng, Ching-Feng; Su, Jui-Hsin; Hwang, Tsong-Long; Wu, Yang-Chang; Sung, Ping-Jyun. 2011. "Discovery of New Eunicellins from an Indonesian Octocoral Cladiella sp.." Mar. Drugs 9, no. 6: 934-943.