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Mar. Drugs 2011, 9(6), 1157-1165; doi:10.3390/md9061157
Article

Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis

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1 The NeaNat Group, Department of Chemistry of Natural Products, University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy 2 Department of Experimental Pharmacology, University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy 3 C.S.I.A.S. (Interdepartmental Service Center for Spectroscopic Analysis), University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy
* Author to whom correspondence should be addressed.
Received: 6 May 2011 / Revised: 31 May 2011 / Accepted: 16 June 2011 / Published: 23 June 2011
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Abstract

Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.
Keywords: ascidians; natural products; alkaloids; bioactive molecules; cytotoxic activity ascidians; natural products; alkaloids; bioactive molecules; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Aiello, A.; Fattorusso, E.; Imperatore, C.; Irace, C.; Luciano, P.; Menna, M.; Santamaria, R.; Vitalone, R. Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis. Mar. Drugs 2011, 9, 1157-1165.

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