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Mar. Drugs 2011, 9(6), 1157-1165; doi:10.3390/md9061157
Article

Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis

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1,* , 2
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1 The NeaNat Group, Department of Chemistry of Natural Products, University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy 2 Department of Experimental Pharmacology, University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy 3 C.S.I.A.S. (Interdepartmental Service Center for Spectroscopic Analysis), University of Napoli “Federico II”, Via D. Montesano 49, Napoli 80131, Italy
* Author to whom correspondence should be addressed.
Received: 6 May 2011 / Revised: 31 May 2011 / Accepted: 16 June 2011 / Published: 23 June 2011
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Abstract

Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.
Keywords: ascidians; natural products; alkaloids; bioactive molecules; cytotoxic activity ascidians; natural products; alkaloids; bioactive molecules; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Aiello, A.; Fattorusso, E.; Imperatore, C.; Irace, C.; Luciano, P.; Menna, M.; Santamaria, R.; Vitalone, R. Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis. Mar. Drugs 2011, 9, 1157-1165.

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