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Mar. Drugs 2011, 9(6), 1157-1165; doi:10.3390/md9061157
Article

Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis

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Received: 6 May 2011; in revised form: 31 May 2011 / Accepted: 16 June 2011 / Published: 23 June 2011
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Abstract: Chemical analysis of the Mediterranean ascidian Polyandrocarpa zorritensis (Van Name 1931) resulted in the isolation of a series of molecules including two monoindole alkaloids, 3-indolylglyoxylic acid (3) and its methyl ester (4), 4-hydroxy-3-methoxyphenylglyoxylic acid methyl ester (1) and a new alkaloid we named zorrimidazolone (2). The structure of the novel compound 2 has been elucidated by spectroscopic analysis and bioactivity of all compounds has been investigated. Zorrimidazolone (2) showed a modest cytotoxic activity against C6 rat glioma cell line.
Keywords: ascidians; natural products; alkaloids; bioactive molecules; cytotoxic activity ascidians; natural products; alkaloids; bioactive molecules; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Aiello, A.; Fattorusso, E.; Imperatore, C.; Irace, C.; Luciano, P.; Menna, M.; Santamaria, R.; Vitalone, R. Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis. Mar. Drugs 2011, 9, 1157-1165.

AMA Style

Aiello A, Fattorusso E, Imperatore C, Irace C, Luciano P, Menna M, Santamaria R, Vitalone R. Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis. Marine Drugs. 2011; 9(6):1157-1165.

Chicago/Turabian Style

Aiello, Anna; Fattorusso, Ernesto; Imperatore, Concetta; Irace, Carlo; Luciano, Paolo; Menna, Marialuisa; Santamaria, Rita; Vitalone, Rocco. 2011. "Zorrimidazolone, a Bioactive Alkaloid from the Non-Indigenous Mediterranean Stolidobranch Polyandrocarpa zorritensis." Mar. Drugs 9, no. 6: 1157-1165.



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