Mar. Drugs 2011, 9(5), 879-888; doi:10.3390/md9050879
Article

Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.

Received: 13 April 2011; in revised form: 16 May 2011 / Accepted: 17 May 2011 / Published: 24 May 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A2 (PLA2), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-l-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
Keywords: indole derivatives; bromoindoles; marine sponge; Rhopaloeides odorabile; Hyrtios sp.; PLA2 inhibitor; antioxidant; cytotoxic
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MDPI and ACS Style

Longeon, A.; Copp, B.R.; Quévrain, E.; Roué, M.; Kientz, B.; Cresteil, T.; Petek, S.; Debitus, C.; Bourguet-Kondracki, M.-L. Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.. Mar. Drugs 2011, 9, 879-888.

AMA Style

Longeon A, Copp BR, Quévrain E, Roué M, Kientz B, Cresteil T, Petek S, Debitus C, Bourguet-Kondracki M-L. Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.. Marine Drugs. 2011; 9(5):879-888.

Chicago/Turabian Style

Longeon, Arlette; Copp, Brent R.; Quévrain, Elodie; Roué, Mélanie; Kientz, Betty; Cresteil, Thierry; Petek, Sylvain; Debitus, Cécile; Bourguet-Kondracki, Marie-Lise. 2011. "Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.." Mar. Drugs 9, no. 5: 879-888.

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