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Mar. Drugs 2011, 9(5), 879-888; doi:10.3390/md9050879
Article

Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.

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1 Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d’Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France 2 Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand 3 Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Centre de Recherche de Gif, avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France 4 Centre Polynésien de Recherche sur la Biodiversité Insulaire, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, Polynésie française, France
* Author to whom correspondence should be addressed.
Received: 13 April 2011 / Revised: 16 May 2011 / Accepted: 17 May 2011 / Published: 24 May 2011
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Abstract

Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A2 (PLA2), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-l-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
Keywords: indole derivatives; bromoindoles; marine sponge; Rhopaloeides odorabile; Hyrtios sp.; PLA2 inhibitor; antioxidant; cytotoxic indole derivatives; bromoindoles; marine sponge; Rhopaloeides odorabile; Hyrtios sp.; PLA2 inhibitor; antioxidant; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Longeon, A.; Copp, B.R.; Quévrain, E.; Roué, M.; Kientz, B.; Cresteil, T.; Petek, S.; Debitus, C.; Bourguet-Kondracki, M.-L. Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.. Mar. Drugs 2011, 9, 879-888.

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