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Mar. Drugs 2011, 9(5), 696-711; doi:10.3390/md9050696
Article

Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats

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Received: 4 March 2011; in revised form: 12 April 2011 / Accepted: 18 April 2011 / Published: 26 April 2011
(This article belongs to the Special Issue Marine Functional Food)
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Abstract: Care for diabetic wounds remains a significant clinical problem. The present study was aimed at investigating the effect of skin gelatin from Chum Salmon on defective wound repair in the skin of diabetic rats. Full-thickness excisional skin wounds were made in 48 rats, of which 32 were diabetes. The diabetic rats were orally treated daily for 14 days with skin gelatin from Chum Salmon (2 g/kg) or its vehicle. Sixteen non-diabetic control rats received the same amount of water as vehicle-treated non-diabetic rats. Rats were killed to assess the rate of wound closure, microvessel density (MVD), vascular endothelial growth factor (VEGF), hydroxyproline (HP) contents in wound tissues and nitrate in plasma and wound tissue at 7 and 14 days after wounding. Skin gelatin-treated diabetic rats showed a better wound closure, increased MVD, VEGF, hyproxyproline and NO contents and a reduced extent of inflammatory response. All parameters were significant (P < 0.05) in comparison to vehicle-treated diabetic group. In light of our finding that skin gelatin of Chum Salmon promotes skin wound repair in diabetic rats, we propose that oral administration of Chum Salmon skin gelatin might be a beneficial method for treating wound disorders associated with diabetes.
Keywords: skin gelatin; wound healing; diabetic rats; angiogenesis skin gelatin; wound healing; diabetic rats; angiogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, Z.; Zhao, M.; Wang, J.; Ding, Y.; Dai, X.; Li, Y. Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats. Mar. Drugs 2011, 9, 696-711.

AMA Style

Zhang Z, Zhao M, Wang J, Ding Y, Dai X, Li Y. Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats. Marine Drugs. 2011; 9(5):696-711.

Chicago/Turabian Style

Zhang, Zhaofeng; Zhao, Ming; Wang, Junbo; Ding, Ye; Dai, Xiaoqian; Li, Yong. 2011. "Oral Administration of Skin Gelatin Isolated from Chum Salmon (Oncorhynchus keta) Enhances Wound Healing in Diabetic Rats." Mar. Drugs 9, no. 5: 696-711.



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