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Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan
Koyo Chemical Co. Ltd., 2-11-1 Koraku, Bunkyoku, Tokyo 112-0004, Japan
* Author to whom correspondence should be addressed.
Received: 23 March 2011; in revised form: 18 April 2011 / Accepted: 25 April 2011 / Published: 27 April 2011
Abstract: We examined the effects of oral glucosamine hydrochloride (GlcN), N-acetyl-D-glucosamine (GlcNAc) and D-glucose (Glc) administration on plasma total free amino acid (PFAA) concentrations in dogs. The PFAA concentrations increased in the control group and the GlcNAc group at one hour after feeding, and each amino acid concentration increased. On the other hand, in the GlcN group and the Glc group PFAA concentrations decreased at one hour after feeding. A significant decrease in amino acid concentration was observed for glutamate, glycine and alanine. Our results suggest the existence of differences in PFAA dynamics after oral administration of GlcN and GlcNAc in dogs.
Keywords: glucosamine hydrochloride; N-acetyl-D-glucosamine; amino acid; dog
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Azuma, K.; Osaki, T.; Tsuka, T.; Imagawa, T.; Okamoto, Y.; Takamori, Y.; Minami, S. Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs. Mar. Drugs 2011, 9, 712-718.
Azuma K, Osaki T, Tsuka T, Imagawa T, Okamoto Y, Takamori Y, Minami S. Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs. Marine Drugs. 2011; 9(5):712-718.
Azuma, Kazuo; Osaki, Tomohiro; Tsuka, Takeshi; Imagawa, Tomohiro; Okamoto, Yoshiharu; Takamori, Yoshimori; Minami, Saburo. 2011. "Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs." Mar. Drugs 9, no. 5: 712-718.