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Mar. Drugs 2011, 9(5), 712-718; doi:10.3390/md9050712

Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs

Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan
Koyo Chemical Co. Ltd., 2-11-1 Koraku, Bunkyoku, Tokyo 112-0004, Japan
Author to whom correspondence should be addressed.
Received: 23 March 2011 / Revised: 18 April 2011 / Accepted: 25 April 2011 / Published: 27 April 2011
(This article belongs to the Special Issue Marine Functional Food)
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We examined the effects of oral glucosamine hydrochloride (GlcN), N-acetyl-D-glucosamine (GlcNAc) and D-glucose (Glc) administration on plasma total free amino acid (PFAA) concentrations in dogs. The PFAA concentrations increased in the control group and the GlcNAc group at one hour after feeding, and each amino acid concentration increased. On the other hand, in the GlcN group and the Glc group PFAA concentrations decreased at one hour after feeding. A significant decrease in amino acid concentration was observed for glutamate, glycine and alanine. Our results suggest the existence of differences in PFAA dynamics after oral administration of GlcN and GlcNAc in dogs.
Keywords: glucosamine hydrochloride; N-acetyl-D-glucosamine; amino acid; dog glucosamine hydrochloride; N-acetyl-D-glucosamine; amino acid; dog
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Azuma, K.; Osaki, T.; Tsuka, T.; Imagawa, T.; Okamoto, Y.; Takamori, Y.; Minami, S. Effects of Oral Glucosamine Hydrochloride Administration on Plasma Free Amino Acid Concentrations in Dogs. Mar. Drugs 2011, 9, 712-718.

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