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Mar. Drugs 2011, 9(5), 690-695; doi:10.3390/md9050690

Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus

1,* , 2
1 Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China 2 Liaoning Norm University, Dalian 116029, China 3 Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China 4 Key Laboratory of Marine Bio-resources Sustainable Utilization in Liaoning Province’s University, Dalian Fisheries University, Dalian 116023, China 5 Flinders Centre for Marine Bioprocessing and Bioproducts, School of Medicine, Flinders University, Adelaide, SA 5042, Australia
* Authors to whom correspondence should be addressed.
Received: 9 March 2011 / Revised: 3 April 2011 / Accepted: 13 April 2011 / Published: 26 April 2011
(This article belongs to the Special Issue Biomedicines from Marine Symbioses)
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One new nucleoside derivative, named 3-acetyl-5-methyl-2′-deoxyuridine (1), along with two known compounds 3,5-dimethyl-2′-deoxyuridine (2) and 3-methyl-2′-deoxyuridine (3), were isolated from the cultures of Streptomyces microflavus. This strain was an associated actinomycete isolated from the marine sponge Hymeniacidon perlevis collected from the coast of Dalian (China). Their structures were elucidated by detailed NMR and MS spectroscopic analysis as well as comparison with literature data.
Keywords: actinomycete; Streptomyces microflavus; Hymeniacidon perlevis; deoxyuridine actinomycete; Streptomyces microflavus; Hymeniacidon perlevis; deoxyuridine
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, K.; Li, Q.-L.; Ji, N.-Y.; Liu, B.; Zhang, W.; Cao, X.-P. Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus. Mar. Drugs 2011, 9, 690-695.

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