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Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae
National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, B3H 3Z1, Canada
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China
National Research Council Canada, Institute for Nutrisciences and Health, Charlottetown, PEI, C1A 4P3, Canada
* Authors to whom correspondence should be addressed.
Received: 22 December 2010; in revised form: 15 January 2011 / Accepted: 26 January 2011 / Published: 8 February 2011
Abstract: Sulfated polysaccharides and their lower molecular weight oligosaccharide derivatives from marine macroalgae have been shown to possess a variety of biological activities. The present paper will review the recent progress in research on the structural chemistry and the bioactivities of these marine algal biomaterials. In particular, it will provide an update on the structural chemistry of the major sulfated polysaccharides synthesized by seaweeds including the galactans (e.g., agarans and carrageenans), ulvans, and fucans. It will then review the recent findings on the anticoagulant/antithrombotic, antiviral, immuno-inflammatory, antilipidemic and antioxidant activities of sulfated polysaccharides and their potential for therapeutic application.
Keywords: sulfated polysaccharide; marine macroalgae; carbohydrate structure; bioactivity; oligosaccharides
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Cite This Article
MDPI and ACS Style
Jiao, G.; Yu, G.; Zhang, J.; Ewart, H.S. Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae. Mar. Drugs 2011, 9, 196-223.
Jiao G, Yu G, Zhang J, Ewart HS. Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae. Marine Drugs. 2011; 9(2):196-223.
Jiao, Guangling; Yu, Guangli; Zhang, Junzeng; Ewart, H. S. 2011. "Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae." Mar. Drugs 9, no. 2: 196-223.