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New Cytotoxic Oxygenated Sterols from the Marine Bryozoan Cryptosula pallasiana
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shannxi, China
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200433, China
Jiangsu Center for Drug Screening & National Drug Screening Laboratory, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
* Authors to whom correspondence should be addressed.
Received: 18 December 2010; in revised form: 13 January 2011 / Accepted: 24 January 2011 / Published: 28 January 2011
Abstract: Six new sterols (1–6), together with seven known sterols (7–13), were isolated from the CCl4 extract of the marine bryozoan Cryptosula pallasiana, four (3–6) of which have already been reported as synthetic sterols. This is the first time that these compounds (3–6) are reported as natural sterols. The structures of the new compounds were determined on the basis of the extensive spectroscopic analysis, including two-dimensional (2D) NMR and HR-ESI-MS data. Compounds 1–4, 7 and 10–13 were evaluated for their cytotoxicity against HL-60 human myeloid leukemia cell line, and all of the evaluated compounds exhibited moderate cytotoxicity to HL-60 cells with a range of IC50 values from 14.73 to 22.11 µg/mL except for compounds 12 and 13.
Keywords: marine bryozoan; Cryptosula pallasiana; oxygenated sterols; cytotoxicity
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Tian, X.-R.; Tang, H.-F.; Li, Y.-S.; Lin, H.-W.; Chen, X.-L.; Ma, N.; Yao, M.-N.; Zhang, P.-H. New Cytotoxic Oxygenated Sterols from the Marine Bryozoan Cryptosula pallasiana. Mar. Drugs 2011, 9, 162-183.
Tian X-R, Tang H-F, Li Y-S, Lin H-W, Chen X-L, Ma N, Yao M-N, Zhang P-H. New Cytotoxic Oxygenated Sterols from the Marine Bryozoan Cryptosula pallasiana. Marine Drugs. 2011; 9(2):162-183.
Tian, Xiang-Rong; Tang, Hai-Feng; Li, Yu-Shan; Lin, Hou-Wen; Chen, Xiao-Li; Ma, Ning; Yao, Min-Na; Zhang, Ping-Hu. 2011. "New Cytotoxic Oxygenated Sterols from the Marine Bryozoan Cryptosula pallasiana." Mar. Drugs 9, no. 2: 162-183.