Mar. Drugs 2011, 9(12), 2553-2571; doi:10.3390/md9122553
Article

A Kinetic Study of Accumulation and Elimination of Microcystin-LR in Yellow Perch (Perca Flavescens) Tissue and Implications for Human Fish Consumption

1,* email, 1email, 1email, 2,* email and 3email
Received: 20 September 2011; in revised form: 15 November 2011 / Accepted: 2 December 2011 / Published: 8 December 2011
(This article belongs to the Special Issue Algal Toxins)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Fish consumption is a potential route of human exposure to the hepatotoxic microcystins, especially in lakes and reservoirs that routinely experience significant toxic Microcystis blooms. Understanding the rates of uptake and elimination for microcystins as well as the transfer efficiency into tissues of consumers are important for determining the potential for microcystins to be transferred up the food web and for predicting potential human health impacts. The main objective of this work was to conduct laboratory experiments to investigate the kinetics of toxin accumulation in fish tissue. An oral route of exposure was employed in this study, in which juvenile yellow perch (Perca flavescens) were given a single oral dose of 5 or 20 μg of microcystin-LR (MC-LR) via food and accumulation in the muscle, liver, and tank water were measured over 24 h. Peak concentrations of the water soluble fraction of microcystin were generally observed 8–10 h after dosing in the liver and after 12–16 h in the muscle, with a rapid decline in both tissues by 24 h. Up to 99% of the total recoverable (i.e., unbound) microcystin was measured in the tank water by 16 h after exposure. The relatively rapid uptake and elimination of the unbound fraction of microcystin in the liver and muscle of juvenile yellow perch within 24 h of exposure indicates that fish consumption may not be a major route of human exposure to microcystin, particularly in the Great Lakes.
Keywords: microcystin; accumulation; kinetics; yellow perch; Microcystis; Great Lakes; fish consumption
PDF Full-text Download PDF Full-Text [232 KB, Updated Version, uploaded 9 December 2011 12:06 CET]
The original version is still available [230 KB, uploaded 8 December 2011 08:50 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Dyble, J.; Gossiaux, D.; Landrum, P.; Kashian, D.R.; Pothoven, S. A Kinetic Study of Accumulation and Elimination of Microcystin-LR in Yellow Perch (Perca Flavescens) Tissue and Implications for Human Fish Consumption. Mar. Drugs 2011, 9, 2553-2571.

AMA Style

Dyble J, Gossiaux D, Landrum P, Kashian DR, Pothoven S. A Kinetic Study of Accumulation and Elimination of Microcystin-LR in Yellow Perch (Perca Flavescens) Tissue and Implications for Human Fish Consumption. Marine Drugs. 2011; 9(12):2553-2571.

Chicago/Turabian Style

Dyble, Julianne; Gossiaux, Duane; Landrum, Peter; Kashian, Donna R.; Pothoven, Steven. 2011. "A Kinetic Study of Accumulation and Elimination of Microcystin-LR in Yellow Perch (Perca Flavescens) Tissue and Implications for Human Fish Consumption." Mar. Drugs 9, no. 12: 2553-2571.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert