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Mar. Drugs 2011, 9(1), 98-108; doi:10.3390/md9010098
Article

Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment

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Kieler Wirkstoff-Zentrum (KiWiZ) at the IFM-GEOMAR (Leibniz Institute of Marine Sciences), Am Kiel-Kanal 44, 24106 Kiel, Germany Present address: Universität Bonn, Pharmazeutisches Institut, Pharmazeutische Chemie I, An der Immenburg 4, 53121 Bonn, Germany.
* Author to whom correspondence should be addressed.
Received: 22 November 2010 / Revised: 22 December 2010 / Accepted: 13 January 2011 / Published: 14 January 2011
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Abstract

Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.
Keywords: macrolide; Micromonospora; deep sea; natural product; marine macrolide; Micromonospora; deep sea; natural product; marine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gärtner, A.; Ohlendorf, B.; Schulz, D.; Zinecker, H.; Wiese, J.; Imhoff, J.F. Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment. Mar. Drugs 2011, 9, 98-108.

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