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Mar. Drugs 2011, 9(1), 98-108; doi:10.3390/md9010098
Article

Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment

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Kieler Wirkstoff-Zentrum (KiWiZ) at the IFM-GEOMAR (Leibniz Institute of Marine Sciences), Am Kiel-Kanal 44, 24106 Kiel, Germany Present address: Universität Bonn, Pharmazeutisches Institut, Pharmazeutische Chemie I, An der Immenburg 4, 53121 Bonn, Germany.
* Author to whom correspondence should be addressed.
Received: 22 November 2010 / Revised: 22 December 2010 / Accepted: 13 January 2011 / Published: 14 January 2011
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Abstract

Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.
Keywords: macrolide; Micromonospora; deep sea; natural product; marine macrolide; Micromonospora; deep sea; natural product; marine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gärtner, A.; Ohlendorf, B.; Schulz, D.; Zinecker, H.; Wiese, J.; Imhoff, J.F. Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment. Mar. Drugs 2011, 9, 98-108.

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